======= GJC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GJC2
  * **<color #00a2e8>Official Name</color>**: gap junction protein gamma 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57165|57165]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T442|Q5T442]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GJC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GJC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608803|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. {ECO:0000269|PubMed:15192806}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Connexin CCC|
|Connexin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gap junction channel activity involved in cell communication by electrical coupling|
|positive regulation of oligodendrocyte progenitor proliferation|
|proximal neuron projection|
|regulation of oligodendrocyte progenitor proliferation|
|paranode region of axon|
|gap junction|
|cell communication by electrical coupling|
|connexin complex|
|myelin sheath|
|positive regulation of neural precursor cell proliferation|
|positive regulation of gliogenesis|
|positive regulation of calcium ion transmembrane transport|
|regulation of neural precursor cell proliferation|
|negative regulation of G1/S transition of mitotic cell cycle|
|negative regulation of cell cycle G1/S phase transition|
|regulation of gliogenesis|
|positive regulation of calcium ion transport|
|perikaryon|
|positive regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transport|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of ion transmembrane transport|
|regulation of cell cycle G1/S phase transition|
|positive regulation of transmembrane transport|
|negative regulation of mitotic cell cycle phase transition|
|negative regulation of cell cycle phase transition|
|regulation of calcium ion transport|
|positive regulation of ion transport|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|positive regulation of neurogenesis|
|regulation of ion transmembrane transport|
|response to toxic substance|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of transmembrane transport|
|negative regulation of cell cycle|
|regulation of mitotic cell cycle|
|regulation of ion transport|
|brain development|
|regulation of cell cycle process|
|head development|
|regulation of neurogenesis|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|central nervous system development|
|positive regulation of transport|
|cell-cell signaling|
|regulation of cell cycle|
|transmembrane transport|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7493
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GJC2 Expression in NALM6 Cells: -1.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>