======= GLI2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GLI2
  * **<color #00a2e8>Official Name</color>**: GLI family zinc finger 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2736|2736]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10070|P10070]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GLI2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GLI2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/165230|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}. Isoform 5: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|floor plate formation|
|notochord regression|
|floor plate morphogenesis|
|smoothened signaling pathway involved in spinal cord motor neuron cell fate specification|
|spinal cord ventral commissure morphogenesis|
|smoothened signaling pathway involved in ventral spinal cord interneuron specification|
|ventral midline development|
|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|
|prostatic bud formation|
|smoothened signaling pathway involved in ventral spinal cord patterning|
|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|
|morphogenesis of an epithelial bud|
|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|
|floor plate development|
|hindgut morphogenesis|
|positive regulation of cerebellar granule cell precursor proliferation|
|hindgut development|
|lateral sprouting from an epithelium|
|regulation of cerebellar granule cell precursor proliferation|
|notochord morphogenesis|
|anatomical structure regression|
|cell fate specification involved in pattern specification|
|ventral spinal cord interneuron specification|
|positive regulation of T cell differentiation in thymus|
|spinal cord motor neuron cell fate specification|
|cell fate commitment involved in pattern specification|
|ventral spinal cord interneuron fate commitment|
|ventral spinal cord interneuron differentiation|
|dorsal/ventral neural tube patterning|
|morphogenesis of an epithelial fold|
|osteoblast development|
|notochord development|
|spinal cord dorsal/ventral patterning|
|negative regulation of chondrocyte differentiation|
|prostate gland epithelium morphogenesis|
|prostate gland morphogenesis|
|cochlea morphogenesis|
|regulation of T cell differentiation in thymus|
|spinal cord patterning|
|central nervous system projection neuron axonogenesis|
|negative regulation of cartilage development|
|cerebellar cortex morphogenesis|
|proximal/distal pattern formation|
|mammary gland duct morphogenesis|
|neuron fate specification|
|spinal cord motor neuron differentiation|
|embryonic digestive tract development|
|neural tube patterning|
|animal organ formation|
|central nervous system neuron axonogenesis|
|ciliary base|
|positive regulation of DNA replication|
|cerebellum morphogenesis|
|hindbrain morphogenesis|
|prostate gland development|
|pituitary gland development|
|mammary gland morphogenesis|
|ciliary tip|
|cerebellar cortex development|
|digestive tract morphogenesis|
|ventral spinal cord development|
|promoter-specific chromatin binding|
|regulation of chondrocyte differentiation|
|cochlea development|
|positive regulation of neural precursor cell proliferation|
|cell differentiation in spinal cord|
|mammary gland epithelium development|
|embryonic digit morphogenesis|
|neuron fate commitment|
|regulation of cartilage development|
|smoothened signaling pathway|
|diencephalon development|
|central nervous system neuron development|
|dorsal/ventral pattern formation|
|chondrocyte differentiation|
|odontogenesis of dentin-containing tooth|
|positive regulation of T cell differentiation|
|cell fate specification|
|regulation of neural precursor cell proliferation|
|positive regulation of lymphocyte differentiation|
|inner ear morphogenesis|
|gland morphogenesis|
|motile cilium|
|cerebellum development|
|axoneme|
|spinal cord development|
|regulation of DNA replication|
|metencephalon development|
|ear morphogenesis|
|odontogenesis|
|endocrine system development|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|osteoblast differentiation|
|mammary gland development|
|digestive tract development|
|branching morphogenesis of an epithelial tube|
|regulation of T cell differentiation|
|digestive system development|
|morphogenesis of embryonic epithelium|
|positive regulation of leukocyte differentiation|
|appendage morphogenesis|
|limb morphogenesis|
|hindbrain development|
|morphogenesis of a branching epithelium|
|neural tube development|
|morphogenesis of a branching structure|
|regulation of lymphocyte differentiation|
|lung development|
|cartilage development|
|respiratory tube development|
|central nervous system neuron differentiation|
|appendage development|
|limb development|
|positive regulation of hemopoiesis|
|inner ear development|
|respiratory system development|
|cilium|
|positive regulation of T cell activation|
|positive regulation of leukocyte cell-cell adhesion|
|anterior/posterior pattern specification|
|ear development|
|connective tissue development|
|cell fate commitment|
|positive regulation of cell-cell adhesion|
|sensory organ morphogenesis|
|axon guidance|
|neuron projection guidance|
|ossification|
|kidney development|
|regulation of leukocyte differentiation|
|renal system development|
|embryonic organ morphogenesis|
|regulation of leukocyte cell-cell adhesion|
|epithelial tube morphogenesis|
|regulation of T cell activation|
|urogenital system development|
|transcription factor binding|
|regionalization|
|positive regulation of lymphocyte activation|
|positive regulation of neuron differentiation|
|axonogenesis|
|in utero embryonic development|
|forebrain development|
|developmental growth|
|growth|
|regulation of cell-cell adhesion|
|nuclear speck|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|axon development|
|gland development|
|positive regulation of cell activation|
|sequence-specific DNA binding|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cell part morphogenesis|
|regulation of lymphocyte activation|
|heart development|
|positive regulation of nervous system development|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|sensory organ development|
|chemotaxis|
|taxis|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|regulation of leukocyte activation|
|chordate embryonic development|
|regulation of cell activation|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|regulation of cell adhesion|
|negative regulation of cell differentiation|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|zinc ion binding|
|tube development|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|neuron differentiation|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6265
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GLI2 Expression in NALM6 Cells: 0.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>