======= GLTSCR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOP53
  * **<color #00a2e8>Official Name</color>**: NOP53 ribosome biogenesis factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29997|29997]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZM5|Q9NZM5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GLTSCR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GLTSCR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605691|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868). In ribosome biogenesis, may also play a role in rRNA transcription (PubMed:27729611). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214). DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:24120868, PubMed:27829214). It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation (PubMed:22522597). Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway (PubMed:15355975, PubMed:16971513, PubMed:27729611). May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 (PubMed:21167305). May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation (PubMed:25818168). Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex (PubMed:25956029). May also regulate cellular aerobic respiration (PubMed:24556985). In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of DDX58/RIG-1 (PubMed:27824081). {ECO:0000269|PubMed:15355975, ECO:0000269|PubMed:16971513, ECO:0000269|PubMed:21167305, ECO:0000269|PubMed:21741933, ECO:0000269|PubMed:22522597, ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:24556985, ECO:0000269|PubMed:25818168, ECO:0000269|PubMed:25956029, ECO:0000269|PubMed:27729611, ECO:0000269|PubMed:27824081, ECO:0000269|PubMed:27829214}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nop53|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of protein K63-linked deubiquitination|
|regulation of protein K63-linked deubiquitination|
|protein localization to nucleoplasm|
|negative regulation of transcription of nucleolar large rRNA by RNA polymerase I|
|rDNA heterochromatin|
|negative regulation of transcription by RNA polymerase I|
|protein localization to nucleolus|
|positive regulation of protein deubiquitination|
|regulation of aerobic respiration|
|5S rRNA binding|
|regulation of protein deubiquitination|
|negative regulation of phosphatidylinositol 3-kinase signaling|
|regulation of transcription of nucleolar large rRNA by RNA polymerase I|
|mitotic G2 DNA damage checkpoint|
|regulation of RIG-I signaling pathway|
|regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|mitotic G2/M transition checkpoint|
|G2 DNA damage checkpoint|
|regulation of cellular respiration|
|ribosomal large subunit assembly|
|negative regulation of signal transduction by p53 class mediator|
|regulation of transcription by RNA polymerase I|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of protein kinase B signaling|
|negative regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of proteasomal protein catabolic process|
|ribosome assembly|
|p53 binding|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|ribosomal large subunit biogenesis|
|regulation of defense response to virus|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of cellular protein catabolic process|
|negative regulation of G2/M transition of mitotic cell cycle|
|mitotic DNA damage checkpoint|
|positive regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle G2/M phase transition|
|mitotic DNA integrity checkpoint|
|positive regulation of proteasomal protein catabolic process|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of protein complex assembly|
|DNA damage checkpoint|
|negative regulation of protein catabolic process|
|fibrillar center|
|positive regulation of protein modification by small protein conjugation or removal|
|positive regulation of cellular protein catabolic process|
|DNA integrity checkpoint|
|mitotic cell cycle checkpoint|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of generation of precursor metabolites and energy|
|protein localization to nucleus|
|protein stabilization|
|regulation of signal transduction by p53 class mediator|
|regulation of proteasomal protein catabolic process|
|cellular response to hypoxia|
|cell cycle checkpoint|
|regulation of G2/M transition of mitotic cell cycle|
|cellular response to decreased oxygen levels|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|rRNA processing|
|cellular response to oxygen levels|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of protein kinase B signaling|
|rRNA metabolic process|
|regulation of protein modification by small protein conjugation or removal|
|negative regulation of cell cycle phase transition|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|regulation of protein stability|
|ribosome biogenesis|
|negative regulation of mitotic cell cycle|
|negative regulation of catabolic process|
|negative regulation of cell cycle process|
|response to hypoxia|
|negative regulation of proteolysis|
|response to decreased oxygen levels|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|response to oxygen levels|
|regulation of protein catabolic process|
|ncRNA processing|
|regulation of mitotic cell cycle phase transition|
|positive regulation of catabolic process|
|regulation of cell cycle phase transition|
|regulation of protein complex assembly|
|regulation of innate immune response|
|ribonucleoprotein complex biogenesis|
|regulation of immune effector process|
|ncRNA metabolic process|
|negative regulation of intracellular signal transduction|
|DNA repair|
|regulation of response to biotic stimulus|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|intracellular membrane-bounded organelle|
|regulation of cytokine production|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|protein localization to organelle|
|DNA metabolic process|
|regulation of cell cycle process|
|organelle assembly|
|regulation of defense response|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|RNA processing|
|regulation of cellular component biogenesis|
|regulation of catabolic process|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|identical protein binding|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|regulation of immune response|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-1.83|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.8|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.73|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|1.73|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.74|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.89|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.91|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.99|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|2.06|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|2.08|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.11|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2.11|
|[[:results:exp495|IWR1 50μM R08 exp495]]|2.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.552|
|[[:human genes:p:psmb4|PSMB4]]|0.435|
|[[:human genes:r:rps7|RPS7]]|0.432|
|[[:human genes:a:ahctf1|AHCTF1]]|0.427|
|[[:human genes:p:psma6|PSMA6]]|0.421|
|[[:human genes:d:dtl|DTL]]|0.411|
|[[:human genes:p:psmb1|PSMB1]]|0.406|
|[[:human genes:c:ccna2|CCNA2]]|0.402|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.402|
|[[:human genes:d:dhx38|DHX38]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 80/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|3/28|
|blood|2/28|
|bone|3/26|
|breast|2/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|0/21|
|liver|0/20|
|lung|13/75|
|lymphocyte|4/16|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|3/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|2/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1067
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.85 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GLTSCR2 Expression in NALM6 Cells: 7.85'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>