======= GNAI2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNAI2
  * **<color #00a2e8>Official Name</color>**: G protein subunit alpha i2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2771|2771]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04899|P04899]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNAI2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNAI2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139360|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arf|
|G-alpha|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process|
|regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process|
|negative regulation of protein tyrosine phosphatase activity|
|negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway|
|regulation of protein tyrosine phosphatase activity|
|positive regulation of NAD(P)H oxidase activity|
|negative regulation of calcium ion-dependent exocytosis|
|negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|adenosine receptor signaling pathway|
|regulation of NAD(P)H oxidase activity|
|regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|positive regulation of urine volume|
|positive regulation of renal sodium excretion|
|negative regulation of adenylate cyclase activity|
|positive regulation of superoxide anion generation|
|G protein-coupled acetylcholine receptor signaling pathway|
|G-protein beta/gamma-subunit complex binding|
|G protein-coupled purinergic receptor signaling pathway|
|negative regulation of cyclase activity|
|regulation of renal sodium excretion|
|negative regulation of lyase activity|
|regulation of urine volume|
|regulation of superoxide anion generation|
|positive regulation of insulin receptor signaling pathway|
|negative regulation of cAMP-mediated signaling|
|regulation of excretion|
|positive regulation of cellular response to insulin stimulus|
|negative regulation of regulated secretory pathway|
|gamma-aminobutyric acid signaling pathway|
|regulation of adenylate cyclase activity|
|purinergic receptor signaling pathway|
|acetylcholine receptor signaling pathway|
|heterotrimeric G-protein complex|
|cellular response to acetylcholine|
|response to acetylcholine|
|regulation of superoxide metabolic process|
|positive regulation of vascular smooth muscle cell proliferation|
|negative regulation of exocytosis|
|regulation of renal system process|
|postsynaptic signal transduction|
|regulation of cyclase activity|
|regulation of calcium ion-dependent exocytosis|
|regulation of lyase activity|
|negative regulation of G protein-coupled receptor signaling pathway|
|regulation of cAMP-mediated signaling|
|regulation of vascular smooth muscle cell proliferation|
|positive regulation of neural precursor cell proliferation|
|positive regulation of oxidoreductase activity|
|extracellular vesicle|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of synaptic transmission|
|regulation of insulin receptor signaling pathway|
|negative regulation of protein dephosphorylation|
|G protein-coupled receptor binding|
|cell body|
|regulation of cellular response to insulin stimulus|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|positive regulation of smooth muscle cell proliferation|
|regulation of neural precursor cell proliferation|
|signal transduction involved in cellular response to ammonium ion|
|regulation of oxidoreductase activity|
|positive regulation of reactive oxygen species metabolic process|
|negative regulation of phosphatase activity|
|renal system process|
|negative regulation of dephosphorylation|
|regulation of phosphoprotein phosphatase activity|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cellular response to ammonium ion|
|regulation of smooth muscle cell proliferation|
|regulation of protein dephosphorylation|
|regulation of G protein-coupled receptor signaling pathway|
|cAMP-mediated signaling|
|midbody|
|regulation of regulated secretory pathway|
|cyclic-nucleotide-mediated signaling|
|regulation of phosphatase activity|
|regulation of reactive oxygen species metabolic process|
|response to ammonium ion|
|negative regulation of secretion by cell|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of dephosphorylation|
|response to nutrient|
|regulation of exocytosis|
|membrane raft|
|negative regulation of apoptotic signaling pathway|
|protein folding|
|negative regulation of secretion|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of calcium ion transport|
|regulation of ERK1 and ERK2 cascade|
|GTPase activity|
|second-messenger-mediated signaling|
|regulation of metal ion transport|
|GTP binding|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|dendrite|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of hydrolase activity|
|synaptic signaling|
|negative regulation of transport|
|centrosome|
|cell division|
|regulation of body fluid levels|
|response to nutrient levels|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|positive regulation of cell motility|
|response to extracellular stimulus|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|cell population proliferation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of system process|
|negative regulation of protein modification process|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|regulation of ion transport|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of secretion|
|regulation of cell migration|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.36|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13078
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNAI2 Expression in NALM6 Cells: 7.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>