======= GNAT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNAT1
  * **<color #00a2e8>Official Name</color>**: G protein subunit alpha transducin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2779|2779]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11488|P11488]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNAT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNAT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139330|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (PubMed:22190596). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity). {ECO:0000250|UniProtKB:P04695, ECO:0000269|PubMed:22190596}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arf|
|G-alpha|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acyl binding|
|negative regulation of cyclic-nucleotide phosphodiesterase activity|
|positive regulation of cyclic-nucleotide phosphodiesterase activity|
|sensory perception of umami taste|
|regulation of cyclic-nucleotide phosphodiesterase activity|
|cellular response to electrical stimulus|
|response to light intensity|
|rhodopsin mediated signaling pathway|
|photoreceptor outer segment membrane|
|detection of light stimulus involved in visual perception|
|detection of light stimulus involved in sensory perception|
|phototransduction, visible light|
|G-protein beta/gamma-subunit complex binding|
|photoreceptor disc membrane|
|regulation of rhodopsin mediated signaling pathway|
|heterotrimeric G-protein complex|
|eye photoreceptor cell development|
|photoreceptor connecting cilium|
|detection of chemical stimulus involved in sensory perception of bitter taste|
|response to electrical stimulus|
|phototransduction|
|eye photoreceptor cell differentiation|
|sensory perception of bitter taste|
|photoreceptor cell development|
|detection of visible light|
|detection of chemical stimulus involved in sensory perception of taste|
|photoreceptor inner segment|
|photoreceptor cell differentiation|
|detection of light stimulus|
|photoreceptor outer segment|
|G protein-coupled receptor binding|
|sensory perception of taste|
|GDP binding|
|cellular response to light stimulus|
|detection of external stimulus|
|detection of abiotic stimulus|
|retina development in camera-type eye|
|regulation of G protein-coupled receptor signaling pathway|
|eye morphogenesis|
|cellular response to radiation|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|visual perception|
|sensory perception of light stimulus|
|protein folding|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|sensory organ morphogenesis|
|response to light stimulus|
|camera-type eye development|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|apical plasma membrane|
|GTPase activity|
|eye development|
|visual system development|
|sensory system development|
|neuronal cell body|
|GTP binding|
|response to radiation|
|negative regulation of hydrolase activity|
|protein kinase binding|
|detection of chemical stimulus involved in sensory perception|
|detection of chemical stimulus|
|sensory perception of chemical stimulus|
|detection of stimulus involved in sensory perception|
|sensory organ development|
|cell population proliferation|
|detection of stimulus|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|neuron development|
|animal organ morphogenesis|
|sensory perception|
|neuron differentiation|
|regulation of response to external stimulus|
|negative regulation of molecular function|
|response to abiotic stimulus|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|positive regulation of catalytic activity|
|generation of neurons|
|neurogenesis|
|cell development|
|positive regulation of molecular function|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13783
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNAT1 Expression in NALM6 Cells: -3.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>