======= GNB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNB1
  * **<color #00a2e8>Official Name</color>**: G protein subunit beta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2782|2782]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62873|P62873]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139380|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alkylglycerophosphoethanolamine phosphodiesterase activity|
|striated muscle cell apoptotic process|
|cardiac muscle cell apoptotic process|
|muscle cell apoptotic process|
|adenylate cyclase-activating dopamine receptor signaling pathway|
|rhodopsin mediated signaling pathway|
|protein heterotrimerization|
|cellular response to prostaglandin E stimulus|
|photoreceptor outer segment membrane|
|phototransduction, visible light|
|G protein-coupled acetylcholine receptor signaling pathway|
|cellular response to prostaglandin stimulus|
|photoreceptor disc membrane|
|response to prostaglandin E|
|spectrin binding|
|acetylcholine receptor signaling pathway|
|response to prostaglandin|
|heterotrimeric G-protein complex|
|cellular response to acetylcholine|
|response to acetylcholine|
|GTPase binding|
|dopamine receptor signaling pathway|
|Wnt signaling pathway, calcium modulating pathway|
|postsynaptic signal transduction|
|phototransduction|
|detection of visible light|
|photoreceptor inner segment|
|protein trimerization|
|cellular response to fatty acid|
|extracellular vesicle|
|detection of light stimulus|
|sensory perception of taste|
|cell body|
|cellular response to alcohol|
|response to fatty acid|
|cellular response to dopamine|
|response to dopamine|
|cellular response to ketone|
|signal transduction involved in cellular response to ammonium ion|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|response to monoamine|
|response to catecholamine|
|protein heterooligomerization|
|cellular response to light stimulus|
|detection of external stimulus|
|detection of abiotic stimulus|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cellular response to ammonium ion|
|non-canonical Wnt signaling pathway|
|platelet activation|
|retina development in camera-type eye|
|cAMP-mediated signaling|
|cyclic-nucleotide-mediated signaling|
|cellular response to radiation|
|response to ammonium ion|
|cellular response to hypoxia|
|response to ketone|
|cellular response to decreased oxygen levels|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|cellular response to acid chemical|
|cellular response to oxygen levels|
|protein folding|
|response to alcohol|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|Ras protein signal transduction|
|protein-containing complex binding|
|positive regulation of cytosolic calcium ion concentration|
|blood coagulation|
|coagulation|
|hemostasis|
|lysosomal membrane|
|response to light stimulus|
|camera-type eye development|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|small GTPase mediated signal transduction|
|regulation of cytosolic calcium ion concentration|
|GTPase activity|
|second-messenger-mediated signaling|
|response to hypoxia|
|response to acid chemical|
|Wnt signaling pathway|
|response to decreased oxygen levels|
|cell-cell signaling by wnt|
|eye development|
|visual system development|
|sensory system development|
|response to oxygen levels|
|cellular response to drug|
|dendrite|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|cellular calcium ion homeostasis|
|response to radiation|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|wound healing|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|protein complex oligomerization|
|cellular response to lipid|
|sensory perception of chemical stimulus|
|cellular response to organic cyclic compound|
|sensory organ development|
|cell population proliferation|
|cellular metal ion homeostasis|
|response to wounding|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|detection of stimulus|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|response to organic cyclic compound|
|apoptotic process|
|sensory perception|
|response to organonitrogen compound|
|response to drug|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|cell death|
|chemical homeostasis|
|cell-cell signaling|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|homeostatic process|
|intracellular signal transduction|
|cellular response to stress|
|protein-containing complex subunit organization|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.74|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.83|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|3.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9867
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNB1 Expression in NALM6 Cells: 8.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>