======= GNG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNG2
  * **<color #00a2e8>Official Name</color>**: G protein subunit gamma 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54331|54331]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P59768|P59768]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606981|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G-gamma|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adenylate cyclase-activating dopamine receptor signaling pathway|
|G-protein beta/gamma-subunit complex|
|cellular response to prostaglandin E stimulus|
|G-protein beta-subunit binding|
|cellular response to prostaglandin stimulus|
|response to prostaglandin E|
|response to prostaglandin|
|heterotrimeric G-protein complex|
|dopamine receptor signaling pathway|
|Wnt signaling pathway, calcium modulating pathway|
|cellular response to fatty acid|
|cellular response to alcohol|
|response to fatty acid|
|cellular response to dopamine|
|response to dopamine|
|cellular response to ketone|
|signal transduction involved in cellular response to ammonium ion|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|response to catecholamine|
|response to monoamine|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cellular response to ammonium ion|
|non-canonical Wnt signaling pathway|
|platelet activation|
|cAMP-mediated signaling|
|cyclic-nucleotide-mediated signaling|
|response to ammonium ion|
|response to ketone|
|cellular response to acid chemical|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|protein folding|
|response to alcohol|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|blood coagulation|
|coagulation|
|hemostasis|
|GTPase activity|
|second-messenger-mediated signaling|
|response to acid chemical|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|cellular response to drug|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|wound healing|
|regulation of body fluid levels|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|cell population proliferation|
|response to wounding|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|cell-cell signaling|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-2.42|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.83|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.78|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.71|
|[[:results:exp285|GW501516 25μM R06 exp285]]|1.74|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11868
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNG2 Expression in NALM6 Cells: 4.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>