======= GNPDA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNPDA1
  * **<color #00a2e8>Official Name</color>**: glucosamine-6-phosphate deaminase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10007|10007]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P46926|P46926]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNPDA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNPDA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601798|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glucosamine iso|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glucosamine catabolic process|
|glucosamine-6-phosphate deaminase activity|
|N-acetylglucosamine catabolic process|
|glucosamine metabolic process|
|N-acetylneuraminate catabolic process|
|glucosamine-containing compound catabolic process|
|UDP-N-acetylglucosamine biosynthetic process|
|N-acetylneuraminate metabolic process|
|amino sugar catabolic process|
|amino sugar biosynthetic process|
|UDP-N-acetylglucosamine metabolic process|
|N-acetylglucosamine metabolic process|
|nucleotide-sugar biosynthetic process|
|glucosamine-containing compound metabolic process|
|nucleotide-sugar metabolic process|
|amino sugar metabolic process|
|antibiotic catabolic process|
|antibiotic metabolic process|
|single fertilization|
|drug catabolic process|
|fertilization|
|carbohydrate derivative catabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|carbohydrate metabolic process|
|drug metabolic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|sexual reproduction|
|carboxylic acid metabolic process|
|multi-organism reproductive process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|reproductive process|
|reproduction|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13232
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.91 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNPDA1 Expression in NALM6 Cells: 0.91'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>