======= GOSR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GOSR1
  * **<color #00a2e8>Official Name</color>**: golgi SNAP receptor complex member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9527|9527]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95249|O95249]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GOSR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GOSR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604026|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:21860593}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-SNARE C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of vesicle targeting, to, from or within Golgi|
|Golgi medial cisterna|
|SNAP receptor activity|
|intra-Golgi vesicle-mediated transport|
|SNARE complex|
|cis-Golgi network|
|vesicle fusion|
|organelle membrane fusion|
|transport vesicle|
|retrograde transport, endosome to Golgi|
|organelle fusion|
|membrane fusion|
|cytosolic transport|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|endosomal transport|
|vesicle organization|
|Golgi vesicle transport|
|regulation of vesicle-mediated transport|
|Golgi membrane|
|membrane organization|
|regulation of cellular localization|
|Golgi apparatus|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.36|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.91|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.83|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.82|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.78|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.75|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.74|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.74|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.74|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.74|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10375
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GOSR1 Expression in NALM6 Cells: 6.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>