======= GPR116 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADGRF5
  * **<color #00a2e8>Official Name</color>**: adhesion G protein-coupled receptor F5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=221395|221395]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IZF2|Q8IZF2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPR116&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPR116|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620874|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function. {ECO:0000250|UniProtKB:G5E8Q8}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GPS|
|7tm 2|
|SEA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pharyngeal arch artery morphogenesis|
|surfactant homeostasis|
|glomerular filtration|
|positive regulation of phospholipid biosynthetic process|
|renal filtration|
|chemical homeostasis within a tissue|
|negative regulation of macrophage activation|
|regulation of phospholipid biosynthetic process|
|pharyngeal system development|
|erythrocyte development|
|positive regulation of phospholipid metabolic process|
|regulation of macrophage activation|
|myeloid cell development|
|artery morphogenesis|
|energy reserve metabolic process|
|apical part of cell|
|positive regulation of lipid biosynthetic process|
|erythrocyte differentiation|
|regulation of phospholipid metabolic process|
|artery development|
|erythrocyte homeostasis|
|fat cell differentiation|
|myeloid cell homeostasis|
|renal system process|
|positive regulation of lipid metabolic process|
|negative regulation of leukocyte activation|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of lipid biosynthetic process|
|tissue homeostasis|
|negative regulation of cell activation|
|homeostasis of number of cells|
|myeloid cell differentiation|
|energy derivation by oxidation of organic compounds|
|cytoplasmic vesicle|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|regulation of lipid metabolic process|
|blood vessel morphogenesis|
|generation of precursor metabolites and energy|
|negative regulation of immune system process|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|hemopoiesis|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|cell surface|
|chordate embryonic development|
|regulation of cell activation|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|G protein-coupled receptor activity|
|tube development|
|circulatory system development|
|oxidation-reduction process|
|embryo development|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|G protein-coupled receptor signaling pathway|
|homeostatic process|
|cell development|
|regulation of immune system process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4572
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPR116 Expression in NALM6 Cells: -2.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>