======= GPR143 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPR143
  * **<color #00a2e8>Official Name</color>**: G protein-coupled receptor 143
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4935|4935]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51810|P51810]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPR143&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPR143|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300808|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. {ECO:0000269|PubMed:10471510, ECO:0000269|PubMed:16524428, ECO:0000269|PubMed:18697795, ECO:0000269|PubMed:18828673, ECO:0000269|PubMed:19717472}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ocular alb|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|L-DOPA receptor activity|
|L-DOPA binding|
|tyrosine binding|
|regulation of melanosome transport|
|regulation of melanosome organization|
|pigment metabolic process involved in developmental pigmentation|
|eye pigment biosynthetic process|
|eye pigment metabolic process|
|pigment metabolic process involved in pigmentation|
|eye pigmentation|
|dopamine binding|
|melanosome membrane|
|melanosome transport|
|pigment granule transport|
|establishment of melanosome localization|
|calcium-mediated signaling using intracellular calcium source|
|establishment of pigment granule localization|
|melanosome localization|
|melanosome organization|
|pigment granule localization|
|pigment granule organization|
|developmental pigmentation|
|cellular pigmentation|
|pigment biosynthetic process|
|pigment metabolic process|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|pigmentation|
|regulation of calcium-mediated signaling|
|melanosome|
|neuropeptide signaling pathway|
|calcium-mediated signaling|
|establishment of vesicle localization|
|vesicle localization|
|visual perception|
|sensory perception of light stimulus|
|vesicle organization|
|lysosomal membrane|
|apical plasma membrane|
|second-messenger-mediated signaling|
|establishment of organelle localization|
|organelle localization|
|G protein-coupled receptor activity|
|regulation of cellular localization|
|sensory perception|
|Golgi apparatus|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|intracellular signal transduction|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15538
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPR143 Expression in NALM6 Cells: -1.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>