======= GPR37 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPR37
  * **<color #00a2e8>Official Name</color>**: G protein-coupled receptor 37
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2861|2861]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15354|O15354]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPR37&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPR37|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602583|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade. {ECO:0000269|PubMed:11439185, ECO:0000269|PubMed:23690594, ECO:0000269|PubMed:9526070}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|prosaposin receptor activity|
|locomotion involved in locomotory behavior|
|positive regulation of catecholamine metabolic process|
|positive regulation of dopamine metabolic process|
|positive regulation of cellular amine metabolic process|
|dopamine biosynthetic process|
|negative regulation of hydrogen peroxide-induced cell death|
|negative regulation of response to reactive oxygen species|
|catechol-containing compound biosynthetic process|
|catecholamine biosynthetic process|
|regulation of dopamine metabolic process|
|regulation of catecholamine metabolic process|
|negative regulation of cellular response to drug|
|regulation of hydrogen peroxide-induced cell death|
|negative regulation of response to drug|
|dopamine metabolic process|
|phenol-containing compound biosynthetic process|
|regulation of response to reactive oxygen species|
|regulation of cellular response to drug|
|G protein-coupled peptide receptor activity|
|Hsp70 protein binding|
|catechol-containing compound metabolic process|
|catecholamine metabolic process|
|negative regulation of cellular response to oxidative stress|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of response to oxidative stress|
|peptide binding|
|heat shock protein binding|
|regulation of oxidative stress-induced cell death|
|regulation of cellular response to oxidative stress|
|regulation of cellular amine metabolic process|
|phenol-containing compound metabolic process|
|regulation of response to oxidative stress|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|regulation of response to drug|
|ubiquitin ligase complex|
|organic hydroxy compound biosynthetic process|
|ammonium ion metabolic process|
|locomotory behavior|
|receptor complex|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|ubiquitin protein ligase binding|
|organic hydroxy compound metabolic process|
|drug metabolic process|
|positive regulation of MAPK cascade|
|behavior|
|G protein-coupled receptor activity|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|endoplasmic reticulum membrane|
|negative regulation of cell death|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|aromatic compound biosynthetic process|
|positive regulation of protein modification process|
|organic cyclic compound biosynthetic process|
|locomotion|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.88|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-1.71|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.72|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8652
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPR37 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>