======= GPRC5B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPRC5B
  * **<color #00a2e8>Official Name</color>**: G protein-coupled receptor class C group 5 member B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51704|51704]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZH0|Q9NZH0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPRC5B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPRC5B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605948|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of macrophage cytokine production|
|regulation of macrophage cytokine production|
|positive regulation of myeloid leukocyte cytokine production involved in immune response|
|protein kinase activator activity|
|positive regulation of cytokine production involved in immune response|
|positive regulation of protein tyrosine kinase activity|
|G protein-coupled receptor binding|
|regulation of cytokine production involved in immune response|
|regulation of protein tyrosine kinase activity|
|positive regulation of production of molecular mediator of immune response|
|positive regulation of inflammatory response|
|regulation of production of molecular mediator of immune response|
|cytoplasmic vesicle membrane|
|positive regulation of canonical Wnt signaling pathway|
|positive regulation of Wnt signaling pathway|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of peptidyl-tyrosine phosphorylation|
|receptor complex|
|positive regulation of immune effector process|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of canonical Wnt signaling pathway|
|activation of protein kinase activity|
|regulation of inflammatory response|
|regulation of Wnt signaling pathway|
|positive regulation of neuron differentiation|
|positive regulation of cytokine production|
|protein kinase binding|
|regulation of immune effector process|
|positive regulation of neurogenesis|
|positive regulation of defense response|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of kinase activity|
|positive regulation of response to external stimulus|
|cell surface|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|intracellular membrane-bounded organelle|
|regulation of cytokine production|
|G protein-coupled receptor activity|
|regulation of defense response|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|nucleolus|
|positive regulation of immune response|
|regulation of kinase activity|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.15|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.78|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.457|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5078
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPRC5B Expression in NALM6 Cells: 1.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>