======= GPS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPS1
  * **<color #00a2e8>Official Name</color>**: G protein pathway suppressor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2873|2873]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13098|Q13098]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601934|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G- protein- and mitogen-activated protein kinase-mediated signal transduction. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PCI|
|RPN7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein deneddylation|
|GTPase inhibitor activity|
|nucleotide-excision repair, DNA damage recognition|
|inactivation of MAPK activity|
|COP9 signalosome|
|negative regulation of GTPase activity|
|transcription-coupled nucleotide-excision repair|
|negative regulation of MAP kinase activity|
|JNK cascade|
|stress-activated MAPK cascade|
|nucleotide-excision repair|
|negative regulation of protein serine/threonine kinase activity|
|stress-activated protein kinase signaling cascade|
|negative regulation of MAPK cascade|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|protein modification by small protein removal|
|regulation of MAP kinase activity|
|post-translational protein modification|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|negative regulation of hydrolase activity|
|regulation of GTPase activity|
|negative regulation of intracellular signal transduction|
|DNA repair|
|regulation of protein serine/threonine kinase activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|DNA metabolic process|
|regulation of MAPK cascade|
|cellular response to DNA damage stimulus|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|protein phosphorylation|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|intracellular signal transduction|
|cellular response to stress|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.91|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.74|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.82|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.94|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.01|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.04|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|2.08|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|3.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.472|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 557/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|21/28|
|bone|17/26|
|breast|26/33|
|central nervous system|35/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|15/21|
|liver|14/20|
|lung|60/75|
|lymphocyte|11/16|
|ovary|21/26|
|pancreas|22/24|
|peripheral nervous system|6/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|14/24|
|soft tissue|9/9|
|thyroid|1/2|
|upper aerodigestive|19/22|
|urinary tract|21/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1266
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPS1 Expression in NALM6 Cells: 6.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>