======= GRIN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRIN1
  * **<color #00a2e8>Official Name</color>**: glutamate ionotropic receptor NMDA type subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2902|2902]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q05586|Q05586]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRIN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRIN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138249|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lig chan|
|CaM bdg C0|
|ANF receptor|
|Lig chan-Glu bd|
|SBP bac 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|propylene metabolic process|
|olfactory learning|
|cellular alkene metabolic process|
|response to glycine|
|pons maturation|
|olefin metabolic process|
|glutamate-gated calcium ion channel activity|
|conditioned taste aversion|
|male mating behavior|
|hindbrain maturation|
|central nervous system maturation|
|neurotransmitter binding|
|NMDA glutamate receptor activity|
|excitatory chemical synaptic transmission|
|glutamate binding|
|pons development|
|olfactory behavior|
|NMDA selective glutamate receptor complex|
|suckling behavior|
|synaptic cleft|
|prepulse inhibition|
|glycine binding|
|chemosensory behavior|
|mating behavior|
|regulation of respiratory gaseous exchange|
|ionotropic glutamate receptor signaling pathway|
|synaptic membrane|
|startle response|
|regulation of long-term neuronal synaptic plasticity|
|positive regulation of excitatory postsynaptic potential|
|synaptic transmission, glutamatergic|
|reproductive behavior|
|excitatory synapse|
|response to amphetamine|
|long-term memory|
|protein heterotetramerization|
|response to morphine|
|mating|
|response to isoquinoline alkaloid|
|protein localization to postsynaptic membrane|
|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|
|regulation of NMDA receptor activity|
|cellular response to amyloid-beta|
|modulation of excitatory postsynaptic potential|
|glutamate receptor signaling pathway|
|response to amine|
|visual learning|
|response to amyloid-beta|
|terminal bouton|
|integral component of postsynaptic density membrane|
|positive regulation of reactive oxygen species biosynthetic process|
|response to bronchodilator|
|social behavior|
|intraspecies interaction between organisms|
|calcium channel activity|
|regulation of neuronal synaptic plasticity|
|visual behavior|
|positive regulation of calcium ion transport into cytosol|
|protein localization to synapse|
|positive regulation of nervous system process|
|excitatory postsynaptic potential|
|regulation of glutamate receptor signaling pathway|
|calcium ion transmembrane import into cytosol|
|multi-organism behavior|
|chemical synaptic transmission, postsynaptic|
|calcium ion transport into cytosol|
|sensory perception of pain|
|regulation of neurotransmitter receptor activity|
|adult locomotory behavior|
|response to anesthetic|
|associative learning|
|amyloid-beta binding|
|regulation of reactive oxygen species biosynthetic process|
|feeding behavior|
|ephrin receptor signaling pathway|
|cytosolic calcium ion transport|
|regulation of dendrite morphogenesis|
|positive regulation of reactive oxygen species metabolic process|
|regulation of calcium ion transport into cytosol|
|regulation of postsynaptic membrane potential|
|regulation of synapse assembly|
|protein heterooligomerization|
|neuromuscular process|
|metencephalon development|
|response to alkaloid|
|response to amino acid|
|cerebral cortex development|
|memory|
|synaptic vesicle|
|positive regulation of calcium ion transport|
|response to ethanol|
|xenobiotic metabolic process|
|anatomical structure maturation|
|regulation of nervous system process|
|adult behavior|
|negative regulation of neuron apoptotic process|
|calcium-mediated signaling|
|learning|
|dendritic spine|
|protein tetramerization|
|regulation of dendrite development|
|positive regulation of cysteine-type endopeptidase activity|
|hindbrain development|
|positive regulation of synaptic transmission|
|regulation of cation channel activity|
|positive regulation of endopeptidase activity|
|regulation of signaling receptor activity|
|pallium development|
|regulation of reactive oxygen species metabolic process|
|response to ammonium ion|
|regulation of axonogenesis|
|cellular response to xenobiotic stimulus|
|regulation of synaptic plasticity|
|positive regulation of peptidase activity|
|locomotory behavior|
|calcium ion transmembrane transport|
|postsynaptic membrane|
|calmodulin binding|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|response to nutrient|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|protein localization to cell periphery|
|response to alcohol|
|developmental maturation|
|regulation of cysteine-type endopeptidase activity|
|regulation of calcium ion transport|
|calcium ion transport|
|postsynaptic density|
|telencephalon development|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|protein-containing complex binding|
|synapse|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|divalent metal ion transport|
|cognition|
|response to xenobiotic stimulus|
|divalent inorganic cation transport|
|response to antibiotic|
|regulation of cell morphogenesis involved in differentiation|
|response to light stimulus|
|regulation of neuron death|
|neuron projection|
|cellular response to peptide|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|signaling receptor binding|
|second-messenger-mediated signaling|
|response to acid chemical|
|glutamatergic synapse|
|positive regulation of proteolysis|
|negative regulation of response to external stimulus|
|MAPK cascade|
|regulation of metal ion transport|
|forebrain development|
|signal transduction by protein phosphorylation|
|regulation of endopeptidase activity|
|dendrite|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of peptidase activity|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|divalent inorganic cation homeostasis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|response to nutrient levels|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|protein complex oligomerization|
|response to extracellular stimulus|
|cell junction|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|behavior|
|regulation of system process|
|cellular response to organonitrogen compound|
|cation transmembrane transport|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of ion transport|
|cation homeostasis|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|calcium ion binding|
|regulation of proteolysis|
|brain development|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|head development|
|ion homeostasis|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|cation transport|
|sexual reproduction|
|multicellular organism reproduction|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|ion transmembrane transport|
|regulation of cellular component biogenesis|
|sensory perception|
|protein phosphorylation|
|central nervous system development|
|positive regulation of transport|
|negative regulation of cell death|
|multi-organism reproductive process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|response to drug|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|regulation of response to external stimulus|
|chemical homeostasis|
|cell-cell signaling|
|response to abiotic stimulus|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|transmembrane transport|
|phosphorylation|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9797
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRIN1 Expression in NALM6 Cells: 1.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>