======= GRM5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRM5
  * **<color #00a2e8>Official Name</color>**: glutamate metabotropic receptor 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2915|2915]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41594|P41594]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRM5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRM5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604102|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. {ECO:0000269|PubMed:7908515, ECO:0000269|Ref.8}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 3|
|NCD3G|
|ANF receptor|
|GluR Homer-bdg|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential|
|phospholipase C-activating G protein-coupled glutamate receptor signaling pathway|
|regulation of intracellular calcium activated chloride channel activity|
|neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration|
|trans-synaptic signaling by lipid, modulating synaptic transmission|
|trans-synaptic signaling by endocannabinoid, modulating synaptic transmission|
|trans-synaptic signaling by lipid|
|trans-synaptic signaling by endocannabinoid|
|regulation of inorganic anion transmembrane transport|
|modulation of age-related behavioral decline|
|protein tyrosine kinase activator activity|
|regulation of chloride transport|
|regulation of anion channel activity|
|regulation of postsynaptic cytosolic calcium ion concentration|
|trans-synaptic signaling, modulating synaptic transmission|
|G protein-coupled glutamate receptor signaling pathway|
|glutamate receptor activity|
|postsynaptic modulation of chemical synaptic transmission|
|regulation of translational elongation|
|postsynaptic density membrane|
|calcium-mediated signaling using intracellular calcium source|
|protein tyrosine kinase binding|
|regulation of anion transmembrane transport|
|regulation of long-term neuronal synaptic plasticity|
|cellular response to amyloid-beta|
|glutamate receptor signaling pathway|
|response to amyloid-beta|
|regulation of neuronal synaptic plasticity|
|positive regulation of protein tyrosine kinase activity|
|regulation of synaptic transmission, glutamatergic|
|Schaffer collateral - CA1 synapse|
|regulation of protein tyrosine kinase activity|
|regulation of anion transport|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of postsynaptic membrane potential|
|learning|
|calcium-mediated signaling|
|regulation of synaptic plasticity|
|positive regulation of peptidyl-tyrosine phosphorylation|
|locomotory behavior|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|synapse organization|
|regulation of transporter activity|
|aging|
|cognition|
|neuron projection|
|cellular response to peptide|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|regulation of translation|
|regulation of cellular amide metabolic process|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|posttranscriptional regulation of gene expression|
|positive regulation of protein kinase activity|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|behavior|
|positive regulation of kinase activity|
|cellular response to organonitrogen compound|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of kinase activity|
|cellular homeostasis|
|regulation of transferase activity|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.79|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|1.88|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5537
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRM5 Expression in NALM6 Cells: -3.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>