======= GRPEL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRPEL1
  * **<color #00a2e8>Official Name</color>**: GrpE like 1, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80273|80273]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HAV7|Q9HAV7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRPEL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRPEL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606173|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (PubMed:11311562). {ECO:0000250|UniProtKB:P38523, ECO:0000269|PubMed:11311562}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GrpE|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PAM complex, Tim23 associated import motor|
|adenyl-nucleotide exchange factor activity|
|protein import into mitochondrial matrix|
|protein transmembrane import into intracellular organelle|
|intracellular protein transmembrane transport|
|protein targeting to mitochondrion|
|protein transmembrane transport|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|mitochondrial transmembrane transport|
|chaperone binding|
|unfolded protein binding|
|protein import|
|mitochondrial transport|
|protein folding|
|protein targeting|
|mitochondrial matrix|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to organelle|
|protein homodimerization activity|
|intracellular protein transport|
|mitochondrion|
|transmembrane transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.32|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.94|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-1.81|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.8|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.71|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.7|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.72|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.76|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.81|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.85|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.88|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.91|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.91|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.92|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.95|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|2.09|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.09|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.2|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.27|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.28|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.35|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.662|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 641/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|23/28|
|bone|24/26|
|breast|28/33|
|central nervous system|47/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|15/21|
|liver|14/20|
|lung|68/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|20/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|16/22|
|urinary tract|23/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 208
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRPEL1 Expression in NALM6 Cells: 5.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>