======= GSC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GSC
  * **<color #00a2e8>Official Name</color>**: goosecoid homeobox
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=145258|145258]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56915|P56915]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GSC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GSC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138890|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals. {ECO:0000250, ECO:0000269|PubMed:24290375}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neural crest cell fate specification|
|neural crest cell fate commitment|
|stem cell fate specification|
|stem cell fate commitment|
|neural crest formation|
|dorsal/ventral neural tube patterning|
|middle ear morphogenesis|
|signal transduction involved in regulation of gene expression|
|neural tube patterning|
|RNA polymerase II repressing transcription factor binding|
|RNA polymerase II transcription factor binding|
|epithelial to mesenchymal transition|
|dorsal/ventral pattern formation|
|muscle organ morphogenesis|
|cell fate specification|
|neural crest cell differentiation|
|embryonic skeletal system morphogenesis|
|ear morphogenesis|
|embryonic skeletal system development|
|mesenchymal cell differentiation|
|stem cell differentiation|
|gastrulation|
|neural tube development|
|transcription factor complex|
|negative regulation of Wnt signaling pathway|
|ear development|
|mesenchyme development|
|skeletal system morphogenesis|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|cell fate commitment|
|sensory organ morphogenesis|
|nuclear body|
|embryonic organ morphogenesis|
|muscle organ development|
|regionalization|
|regulation of Wnt signaling pathway|
|forebrain development|
|embryonic organ development|
|pattern specification process|
|muscle structure development|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|sensory organ development|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|brain development|
|head development|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of response to stimulus|
|negative regulation of gene expression|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5553
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GSC Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>