======= GSTM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GSTM2
  * **<color #00a2e8>Official Name</color>**: glutathione S-transferase mu 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2946|2946]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P28161|P28161]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GSTM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GSTM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138380|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. {ECO:0000269|PubMed:16549767}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GST N|
|GST C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular detoxification of nitrogen compound|
|regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion|
|nitrobenzene metabolic process|
|regulation of skeletal muscle contraction by calcium ion signaling|
|detoxification of nitrogen compound|
|positive regulation of ryanodine-sensitive calcium-release channel activity|
|cellular response to caffeine|
|glutathione binding|
|negative regulation of ryanodine-sensitive calcium-release channel activity|
|regulation of skeletal muscle contraction|
|cellular response to purine-containing compound|
|xenobiotic catabolic process|
|relaxation of cardiac muscle|
|negative regulation of release of sequestered calcium ion into cytosol|
|positive regulation of sequestering of calcium ion|
|linoleic acid metabolic process|
|response to diuretic|
|response to caffeine|
|negative regulation of calcium ion transport into cytosol|
|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|
|glutathione peroxidase activity|
|relaxation of muscle|
|glutathione derivative metabolic process|
|glutathione derivative biosynthetic process|
|regulation of cardiac muscle contraction by calcium ion signaling|
|benzene-containing compound metabolic process|
|regulation of ryanodine-sensitive calcium-release channel activity|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|glutathione transferase activity|
|negative regulation of calcium-mediated signaling|
|cellular response to alkaloid|
|negative regulation of calcium ion transmembrane transporter activity|
|positive regulation of calcium ion transmembrane transporter activity|
|negative regulation of calcium ion transmembrane transport|
|positive regulation of release of sequestered calcium ion into cytosol|
|positive regulation of calcium-mediated signaling|
|negative regulation of cation channel activity|
|sarcoplasmic reticulum|
|positive regulation of calcium ion transport into cytosol|
|glutathione metabolic process|
|intercellular bridge|
|negative regulation of calcium ion transport|
|positive regulation of cation channel activity|
|positive regulation of calcium ion transmembrane transport|
|negative regulation of ion transmembrane transporter activity|
|regulation of cardiac muscle contraction|
|regulation of release of sequestered calcium ion into cytosol|
|negative regulation of transporter activity|
|negative regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transporter activity|
|cellular oxidant detoxification|
|regulation of striated muscle contraction|
|negative regulation of ion transmembrane transport|
|regulation of calcium-mediated signaling|
|regulation of calcium ion transport into cytosol|
|cellular detoxification|
|positive regulation of ion transmembrane transporter activity|
|unsaturated fatty acid metabolic process|
|positive regulation of transporter activity|
|response to alkaloid|
|long-chain fatty acid metabolic process|
|negative regulation of transmembrane transport|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|detoxification|
|xenobiotic metabolic process|
|positive regulation of cation transmembrane transport|
|calcium-mediated signaling|
|negative regulation of ion transport|
|regulation of calcium ion transmembrane transport|
|response to purine-containing compound|
|positive regulation of ion transmembrane transport|
|regulation of muscle contraction|
|regulation of cation channel activity|
|sulfur compound biosynthetic process|
|cellular response to xenobiotic stimulus|
|cellular modified amino acid metabolic process|
|positive regulation of transmembrane transport|
|cellular response to toxic substance|
|regulation of muscle system process|
|regulation of heart contraction|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|muscle system process|
|response to xenobiotic stimulus|
|fatty acid metabolic process|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|signaling receptor binding|
|second-messenger-mediated signaling|
|enzyme binding|
|sulfur compound metabolic process|
|regulation of metal ion transport|
|cellular response to drug|
|cellular calcium ion homeostasis|
|cofactor metabolic process|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|response to toxic substance|
|negative regulation of intracellular signal transduction|
|peptide metabolic process|
|monocarboxylic acid metabolic process|
|cellular response to organic cyclic compound|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|regulation of system process|
|cellular response to organonitrogen compound|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cellular amide metabolic process|
|protein homodimerization activity|
|cellular homeostasis|
|carboxylic acid metabolic process|
|regulation of cellular localization|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|positive regulation of transport|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|response to nitrogen compound|
|chemical homeostasis|
|negative regulation of molecular function|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|small molecule metabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8978
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GSTM2 Expression in NALM6 Cells: 4.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>