======= GTF3A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GTF3A
  * **<color #00a2e8>Official Name</color>**: general transcription factor IIIA
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2971|2971]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92664|Q92664]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GTF3A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GTF3A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600860|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity). {ECO:0000250|UniProtKB:P17842, ECO:0000269|PubMed:24120868}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|5S rRNA binding|
|rRNA transcription|
|transcription by RNA polymerase III|
|ribosomal large subunit biogenesis|
|ncRNA transcription|
|ribosome biogenesis|
|ribonucleoprotein complex biogenesis|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.85|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.72|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.73|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.76|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.85|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.85|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.89|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.93|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.01|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.03|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.05|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.21|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.29|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.33|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.41|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.44|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.45|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.45|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.47|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|3.02|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.17|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.23|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|4.59|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gtf3c3|GTF3C3]]|0.559|
|[[:human genes:p:pmm2|PMM2]]|0.517|
|[[:human genes:h:heatr3|HEATR3]]|0.515|
|[[:human genes:e:eny2|ENY2]]|0.5|
|[[:human genes:h:hspd1|HSPD1]]|0.497|
|[[:human genes:g:gfpt1|GFPT1]]|0.485|
|[[:human genes:e:eif4e|EIF4E]]|0.484|
|[[:human genes:z:zzz3|ZZZ3]]|0.482|
|[[:human genes:u:uap1|UAP1]]|0.479|
|[[:human genes:t:thg1l|THG1L]]|0.47|
|[[:human genes:s:srp72|SRP72]]|0.464|
|[[:human genes:a:abcf1|ABCF1]]|0.464|
|[[:human genes:p:pam16|PAM16]]|0.461|
|[[:human genes:g:gmppb|GMPPB]]|0.461|
|[[:human genes:r:rnmt|RNMT]]|0.456|
|[[:human genes:p:polr3h|POLR3H]]|0.456|
|[[:human genes:a:alg1|ALG1]]|0.452|
|[[:human genes:n:nae1|NAE1]]|0.451|
|[[:human genes:s:srp19|SRP19]]|0.45|
|[[:human genes:a:apaf1|APAF1]]|0.45|
|[[:human genes:t:tbca|TBCA]]|0.449|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.446|
|[[:human genes:r:rptor|RPTOR]]|0.446|
|[[:human genes:n:nsmce1|NSMCE1]]|0.445|
|[[:human genes:m:mtor|MTOR]]|0.443|
|[[:human genes:p:plaa|PLAA]]|0.441|
|[[:human genes:r:rpl11|RPL11]]|0.44|
|[[:human genes:t:tbp|TBP]]|0.436|
|[[:human genes:h:hars|HARS]]|0.435|
|[[:human genes:m:mars|MARS]]|0.431|
|[[:human genes:d:dpagt1|DPAGT1]]|0.43|
|[[:human genes:t:triap1|TRIAP1]]|0.43|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.429|
|[[:human genes:u:ubqln1|UBQLN1]]|0.427|
|[[:human genes:p:pmpcb|PMPCB]]|0.427|
|[[:human genes:t:tbcd|TBCD]]|0.425|
|[[:human genes:t:tti2|TTI2]]|0.425|
|[[:human genes:m:mfn1|MFN1]]|0.425|
|[[:human genes:u:ube2k|UBE2K]]|0.423|
|[[:human genes:d:dhps|DHPS]]|0.421|
|[[:human genes:s:srp68|SRP68]]|0.419|
|[[:human genes:d:dhdds|DHDDS]]|0.419|
|[[:human genes:p:pelo|PELO]]|0.418|
|[[:human genes:e:eftud1|EFTUD1]]|0.414|
|[[:human genes:a:alg2|ALG2]]|0.413|
|[[:human genes:t:tsen2|TSEN2]]|0.413|
|[[:human genes:s:srp14|SRP14]]|0.413|
|[[:human genes:g:gnb1l|GNB1L]]|0.412|
|[[:human genes:d:dohh|DOHH]]|0.411|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.409|
|[[:human genes:a:atxn10|ATXN10]]|0.407|
|[[:human genes:t:tsen54|TSEN54]]|0.404|
|[[:human genes:v:vdac2|VDAC2]]|0.403|
|[[:human genes:b:bak1|BAK1]]|0.403|
|[[:human genes:d:dr1|DR1]]|0.402|
|[[:human genes:p:ppcs|PPCS]]|0.402|
|[[:human genes:u:uba5|UBA5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 644/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|23/28|
|bone|24/26|
|breast|28/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|12/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|18/21|
|liver|19/20|
|lung|68/75|
|lymphocyte|14/16|
|ovary|22/26|
|pancreas|23/24|
|peripheral nervous system|13/16|
|plasma cell|15/15|
|prostate|0/1|
|skin|18/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|25/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 595
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GTF3A Expression in NALM6 Cells: 6.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>