======= GTPBP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GTPBP2
  * **<color #00a2e8>Official Name</color>**: GTP binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54676|54676]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BX10|Q9BX10]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GTPBP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GTPBP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607434|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GTP EFTU|
|GTP EFTU D3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation elongation factor activity|
|platelet alpha granule lumen|
|translational elongation|
|platelet degranulation|
|GTPase activity|
|translation|
|GTP binding|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|intracellular membrane-bounded organelle|
|regulated exocytosis|
|cellular amide metabolic process|
|exocytosis|
|secretion by cell|
|export from cell|
|secretion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-4.72|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-3.79|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-3.78|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-3.65|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-3.36|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-3.08|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.8|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.75|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-2.7|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.58|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.5|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.27|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-2.03|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.02|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.93|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.91|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.9|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.87|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.83|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.83|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.82|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.77|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.72|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.77|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.8|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.585|
|[[:human genes:k:kpna4|KPNA4]]|0.534|
|[[:human genes:k:kpna3|KPNA3]]|0.489|
|[[:human genes:c:ccdc111|CCDC111]]|0.448|
|[[:human genes:g:gtpbp1|GTPBP1]]|0.432|
|[[:human genes:f:ftsj1|FTSJ1]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13099
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GTPBP2 Expression in NALM6 Cells: 6.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>