======= GUCY2F =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GUCY2F
  * **<color #00a2e8>Official Name</color>**: guanylate cyclase 2F, retinal
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2986|2986]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51841|P51841]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GUCY2F&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GUCY2F|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300041|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
|Guanylate cyc|
|ANF receptor|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptide receptor activity|
|guanylate cyclase activity|
|receptor guanylyl cyclase signaling pathway|
|cGMP biosynthetic process|
|cGMP metabolic process|
|detection of light stimulus involved in visual perception|
|detection of light stimulus involved in sensory perception|
|photoreceptor disc membrane|
|cyclic purine nucleotide metabolic process|
|cyclic nucleotide biosynthetic process|
|nuclear outer membrane|
|cGMP-mediated signaling|
|regulation of rhodopsin mediated signaling pathway|
|cyclic nucleotide metabolic process|
|detection of visible light|
|detection of light stimulus|
|detection of external stimulus|
|detection of abiotic stimulus|
|regulation of G protein-coupled receptor signaling pathway|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|cyclic-nucleotide-mediated signaling|
|signaling receptor activity|
|visual perception|
|sensory perception of light stimulus|
|protein kinase activity|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|response to light stimulus|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|second-messenger-mediated signaling|
|purine-containing compound metabolic process|
|GTP binding|
|response to radiation|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|protein heterodimerization activity|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|detection of stimulus involved in sensory perception|
|carbohydrate derivative biosynthetic process|
|detection of stimulus|
|enzyme linked receptor protein signaling pathway|
|protein homodimerization activity|
|organophosphate metabolic process|
|sensory perception|
|protein phosphorylation|
|carbohydrate derivative metabolic process|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|nervous system process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|intracellular signal transduction|
|small molecule metabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.02|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17252
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GUCY2F Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>