======= GUSB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GUSB
  * **<color #00a2e8>Official Name</color>**: glucuronidase beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2990|2990]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08236|P08236]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GUSB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GUSB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611499|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the degradation of dermatan and keratan sulfates.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco hydro 2 C|
|Glyco hydro 2 N|
|Glyco hydro 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glucuronoside catabolic process|
|glucuronoside metabolic process|
|beta-glucuronidase activity|
|glycoside catabolic process|
|hyaluronan catabolic process|
|glycoside metabolic process|
|hyaluronan metabolic process|
|cellular carbohydrate catabolic process|
|glycosyl compound catabolic process|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|azurophil granule lumen|
|lysosomal lumen|
|mucopolysaccharide metabolic process|
|carbohydrate catabolic process|
|ficolin-1-rich granule lumen|
|glycosyl compound metabolic process|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|cellular carbohydrate metabolic process|
|carbohydrate binding|
|carbohydrate derivative catabolic process|
|protein domain specific binding|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|signaling receptor binding|
|small molecule catabolic process|
|carbohydrate metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|intracellular membrane-bounded organelle|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|carboxylic acid metabolic process|
|leukocyte activation|
|oxoacid metabolic process|
|secretion by cell|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|secretion|
|extracellular space|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-3.07|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9197
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GUSB Expression in NALM6 Cells: 7.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>