======= H2AFZ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: H2AZ1
  * **<color #00a2e8>Official Name</color>**: H2A.Z variant histone 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3015|3015]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0C0S5|P0C0S5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=H2AFZ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20H2AFZ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142763|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. {ECO:0000269|PubMed:15878876}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Histone|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Barr body|
|nuclear heterochromatin|
|nuclear euchromatin|
|RNA polymerase II core promoter sequence-specific DNA binding|
|cellular response to estradiol stimulus|
|nucleosomal DNA binding|
|nucleosome|
|chromatin DNA binding|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|response to estradiol|
|nuclear chromatin|
|protein heterodimerization activity|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|cellular response to hormone stimulus|
|chromatin organization|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|cellular response to oxygen-containing compound|
|chromosome organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|DNA binding|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-2.34|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.71|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.72|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.74|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.74|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.78|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.78|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.8|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.82|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.86|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.87|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.95|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.96|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.97|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.01|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.01|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.03|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.11|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.17|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.22|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|2.29|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.32|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.48|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.68|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|3.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:phf20|PHF20]]|0.491|
|[[:human genes:s:srcap|SRCAP]]|0.433|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.432|
|[[:human genes:h:hist1h2bk|HIST1H2BK]]|0.425|
|[[:human genes:c:ccdc53|CCDC53]]|0.42|
|[[:human genes:r:rictor|RICTOR]]|0.418|
|[[:human genes:p:pgm3|PGM3]]|0.412|
|[[:human genes:k:kdsr|KDSR]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 83/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|11/28|
|bone|8/26|
|breast|1/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|1/20|
|lung|7/75|
|lymphocyte|6/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|6/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1371
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='H2AFZ Expression in NALM6 Cells: 8.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>