======= HADHA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HADHA
  * **<color #00a2e8>Official Name</color>**: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3030|3030]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P40939|P40939]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HADHA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HADHA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600890|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Bifunctional subunit.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|3HCDH|
|3HCDH N|
|ECH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial fatty acid beta-oxidation multienzyme complex|
|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|
|acetyl-CoA C-acetyltransferase activity|
|long-chain-enoyl-CoA hydratase activity|
|cardiolipin acyl-chain remodeling|
|3-hydroxyacyl-CoA dehydrogenase activity|
|enoyl-CoA hydratase activity|
|cardiolipin metabolic process|
|fatty-acyl-CoA binding|
|phosphatidylglycerol metabolic process|
|NAD binding|
|mitochondrial nucleoid|
|fatty acid beta-oxidation|
|fatty acid oxidation|
|lipid oxidation|
|fatty acid catabolic process|
|monocarboxylic acid catabolic process|
|cellular lipid catabolic process|
|lipid modification|
|response to insulin|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|protein-containing complex binding|
|lipid catabolic process|
|glycerophospholipid metabolic process|
|fatty acid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|response to peptide hormone|
|mitochondrial inner membrane|
|small molecule catabolic process|
|response to peptide|
|monocarboxylic acid metabolic process|
|organophosphate metabolic process|
|response to hormone|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|response to nitrogen compound|
|lipid metabolic process|
|mitochondrion|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3618
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HADHA Expression in NALM6 Cells: 7.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>