======= HCFC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HCFC1
  * **<color #00a2e8>Official Name</color>**: host cell factor C1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3054|3054]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51610|P51610]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HCFC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HCFC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300019|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kelch 2|
|Kelch 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|latent virus replication|
|release from viral latency|
|SAGA-type complex|
|histone acetyltransferase activity (H4-K8 specific)|
|histone acetyltransferase activity (H4-K5 specific)|
|histone acetyltransferase activity (H4-K16 specific)|
|viral latency|
|Set1C/COMPASS complex|
|sequence-specific double-stranded DNA binding|
|histone H4-K5 acetylation|
|histone H4-K8 acetylation|
|Ada2/Gcn5/Ada3 transcription activator complex|
|histone H4-K16 acetylation|
|blastocyst hatching|
|organism emergence from protective structure|
|hatching|
|histone acetyltransferase complex|
|MLL1 complex|
|activating transcription factor binding|
|histone H4 acetylation|
|protein binding, bridging|
|blastocyst development|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|protein stabilization|
|protein acylation|
|protein deubiquitination|
|transcription coactivator activity|
|regulation of protein stability|
|axon|
|protein modification by small protein removal|
|cadherin binding|
|peptidyl-lysine modification|
|histone modification|
|neuronal cell body|
|covalent chromatin modification|
|positive regulation of cell cycle|
|in utero embryonic development|
|chromatin binding|
|dendrite|
|mitochondrion organization|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of protein complex assembly|
|cellular response to organic cyclic compound|
|protein-containing complex|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|chromatin organization|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|response to organic cyclic compound|
|regulation of cellular component biogenesis|
|embryo development|
|protein modification by small protein conjugation or removal|
|chromosome organization|
|identical protein binding|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp116|AICAR 240μM R03 exp116]]|-3.67|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.15|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-2.13|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.99|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.94|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.91|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.87|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.81|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-1.78|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.73|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.72|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.73|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.77|
|[[:results:exp303|39°C R06 exp303]]|1.78|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.83|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.87|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.89|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.91|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.96|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.443|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.434|
|[[:human genes:c:cope|COPE]]|0.43|
|[[:human genes:p:psmc1|PSMC1]]|0.427|
|[[:human genes:l:lrr1|LRR1]]|0.424|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.417|
|[[:human genes:p:prim1|PRIM1]]|0.409|
|[[:human genes:p:prpf8|PRPF8]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 683/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|26/26|
|bone|25/25|
|breast|30/30|
|central nervous system|49/49|
|cervix|4/4|
|colorectal|17/17|
|esophagus|11/11|
|fibroblast|1/1|
|gastric|14/14|
|kidney|18/18|
|liver|19/19|
|lung|72/72|
|lymphocyte|14/14|
|ovary|25/25|
|pancreas|22/22|
|peripheral nervous system|15/15|
|plasma cell|12/12|
|prostate|1/1|
|skin|20/20|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/28|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 522
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HCFC1 Expression in NALM6 Cells: 8.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>