======= HCN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HCN1
  * **<color #00a2e8>Official Name</color>**: hyperpolarization activated cyclic nucleotide gated potassium channel 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=348980|348980]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60741|O60741]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HCN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HCN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602780|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. {ECO:0000269|PubMed:15351778, ECO:0000269|PubMed:28086084}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ion trans|
|cNMP binding|
|Ion trans N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|HCN channel complex|
|voltage-gated cation channel activity|
|intracellular cAMP-activated cation channel activity|
|retinal cone cell development|
|apical protein localization|
|retinal cone cell differentiation|
|camera-type eye photoreceptor cell differentiation|
|voltage-gated sodium channel activity|
|cAMP binding|
|potassium channel activity|
|eye photoreceptor cell development|
|eye photoreceptor cell differentiation|
|photoreceptor cell development|
|retina morphogenesis in camera-type eye|
|cellular response to cAMP|
|neural retina development|
|photoreceptor cell differentiation|
|voltage-gated potassium channel activity|
|sodium ion transmembrane transport|
|protein homotetramerization|
|response to cAMP|
|camera-type eye morphogenesis|
|response to organophosphorus|
|retina development in camera-type eye|
|eye morphogenesis|
|protein tetramerization|
|response to purine-containing compound|
|sodium ion transport|
|potassium ion transmembrane transport|
|potassium ion transport|
|sensory organ morphogenesis|
|axon|
|camera-type eye development|
|protein homooligomerization|
|eye development|
|visual system development|
|sensory system development|
|monovalent inorganic cation transport|
|dendrite|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|protein complex oligomerization|
|cellular response to organic cyclic compound|
|sensory organ development|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|cellular response to organonitrogen compound|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|regulation of ion transport|
|neuron development|
|cation transport|
|response to organic cyclic compound|
|ion transmembrane transport|
|animal organ morphogenesis|
|response to organonitrogen compound|
|neuron differentiation|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|response to endogenous stimulus|
|generation of neurons|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|neurogenesis|
|cell development|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.89|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.73|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.78|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.98|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11146
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HCN1 Expression in NALM6 Cells: -3.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>