======= HDAC4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HDAC4
  * **<color #00a2e8>Official Name</color>**: histone deacetylase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9759|9759]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56524|P56524]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HDAC4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HDAC4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605314|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HDAC4 Gln|
|Hist deacetyl|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of male mating behavior|
|regulation of male mating behavior|
|peptidyl-lysine deacetylation|
|cellular response to parathyroid hormone stimulus|
|response to denervation involved in regulation of muscle adaptation|
|NAD-dependent histone deacetylase activity (H3-K14 specific)|
|response to muscle inactivity involved in regulation of muscle adaptation|
|regulation of skeletal muscle fiber development|
|protein deacetylase activity|
|potassium ion binding|
|positive regulation of protein sumoylation|
|histone H4 deacetylation|
|response to muscle inactivity|
|A band|
|response to parathyroid hormone|
|actomyosin|
|negative regulation of glycolytic process|
|negative regulation of pri-miRNA transcription by RNA polymerase II|
|cardiac muscle adaptation|
|cardiac muscle hypertrophy in response to stress|
|muscle hypertrophy in response to stress|
|response to inactivity|
|response to stimulus involved in regulation of muscle adaptation|
|SUMO transferase activity|
|negative regulation of purine nucleotide metabolic process|
|negative regulation of nucleotide metabolic process|
|osteoblast development|
|negative regulation of myotube differentiation|
|histone H3 deacetylation|
|positive regulation of lamellipodium assembly|
|regulation of protein sumoylation|
|negative regulation of ATP metabolic process|
|regulation of cardiac muscle contraction by calcium ion signaling|
|histone deacetylase activity|
|striated muscle adaptation|
|positive regulation of behavior|
|positive regulation of lamellipodium organization|
|cardiac muscle hypertrophy|
|striated muscle hypertrophy|
|regulation of lamellipodium assembly|
|muscle adaptation|
|muscle hypertrophy|
|activating transcription factor binding|
|histone deacetylase complex|
|positive regulation of smooth muscle cell migration|
|negative regulation of striated muscle cell differentiation|
|repressing transcription factor binding|
|regulation of lamellipodium organization|
|regulation of pri-miRNA transcription by RNA polymerase II|
|negative regulation of cellular carbohydrate metabolic process|
|negative regulation of osteoblast differentiation|
|negative regulation of carbohydrate metabolic process|
|regulation of skeletal muscle tissue development|
|promoter-specific chromatin binding|
|histone deacetylation|
|positive regulation of reactive oxygen species biosynthetic process|
|protein deacetylation|
|positive regulation of neuron apoptotic process|
|negative regulation of muscle cell differentiation|
|transcriptional repressor complex|
|regulation of myotube differentiation|
|regulation of smooth muscle cell migration|
|protein deacylation|
|RNA polymerase II transcription factor binding|
|macromolecule deacylation|
|protein sumoylation|
|regulation of behavior|
|negative regulation of ossification|
|regulation of cardiac muscle contraction|
|neuromuscular junction|
|positive regulation of reproductive process|
|cellular response to mechanical stimulus|
|regulation of glycolytic process|
|positive regulation of smooth muscle cell proliferation|
|regulation of reactive oxygen species biosynthetic process|
|regulation of muscle adaptation|
|regulation of carbohydrate catabolic process|
|negative regulation of small molecule metabolic process|
|regulation of striated muscle contraction|
|positive regulation of neuron death|
|positive regulation of reactive oxygen species metabolic process|
|positive regulation of plasma membrane bounded cell projection assembly|
|regulation of striated muscle cell differentiation|
|B cell differentiation|
|histone deacetylase binding|
|regulation of osteoblast differentiation|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|osteoblast differentiation|
|Z disc|
|regulation of striated muscle tissue development|
|regulation of smooth muscle cell proliferation|
|positive regulation of protein modification by small protein conjugation or removal|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|regulation of cellular carbohydrate metabolic process|
|calcium-mediated signaling|
|regulation of muscle cell differentiation|
|B cell activation|
|regulation of generation of precursor metabolites and energy|
|regulation of muscle contraction|
|regulation of reproductive process|
|negative regulation of DNA-binding transcription factor activity|
|chromatin remodeling|
|regulation of reactive oxygen species metabolic process|
|regulation of ossification|
|response to interleukin-1|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of carbohydrate metabolic process|
|regulation of neuron apoptotic process|
|response to mechanical stimulus|
|transcription regulatory region DNA binding|
|regulation of protein binding|
|regulation of protein modification by small protein conjugation or removal|
|regulation of muscle system process|
|regulation of gene expression, epigenetic|
|lymphocyte differentiation|
|cellular response to tumor necrosis factor|
|transcription corepressor activity|
|regulation of heart contraction|
|positive regulation of DNA-binding transcription factor activity|
|ossification|
|response to tumor necrosis factor|
|regulation of blood circulation|
|muscle system process|
|negative regulation of catabolic process|
|regulation of neuron death|
|peptidyl-lysine modification|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|leukocyte differentiation|
|transcription factor binding|
|cellular response to external stimulus|
|second-messenger-mediated signaling|
|histone modification|
|covalent chromatin modification|
|regulation of binding|
|positive regulation of cell projection organization|
|lymphocyte activation|
|sequence-specific DNA binding|
|regulation of small molecule metabolic process|
|regulation of DNA-binding transcription factor activity|
|negative regulation of phosphorylation|
|protein kinase binding|
|skeletal system development|
|inflammatory response|
|positive regulation of cell migration|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|positive regulation of multi-organism process|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of system process|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|chromatin organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|zinc ion binding|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|response to drug|
|chromosome organization|
|identical protein binding|
|cell activation|
|response to cytokine|
|negative regulation of molecular function|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp285|GW501516 25μM R06 exp285]]|-2.08|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.76|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.72|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.76|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.8|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4803
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HDAC4 Expression in NALM6 Cells: 3.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>