======= HDAC7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HDAC7
  * **<color #00a2e8>Official Name</color>**: histone deacetylase 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51564|51564]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WUI4|Q8WUI4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HDAC7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HDAC7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606542|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hist deacetyl|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NAD-dependent histone deacetylase activity (H3-K14 specific)|
|histone H3 deacetylation|
|positive regulation of cell migration involved in sprouting angiogenesis|
|negative regulation of NIK/NF-kappaB signaling|
|negative regulation of interleukin-2 production|
|14-3-3 protein binding|
|activating transcription factor binding|
|histone deacetylase complex|
|regulation of cell migration involved in sprouting angiogenesis|
|repressing transcription factor binding|
|positive regulation of sprouting angiogenesis|
|negative regulation of osteoblast differentiation|
|histone deacetylation|
|protein deacetylation|
|protein kinase C binding|
|regulation of interleukin-2 production|
|positive regulation of blood vessel endothelial cell migration|
|protein deacylation|
|macromolecule deacylation|
|vasculogenesis|
|regulation of sprouting angiogenesis|
|negative regulation of ossification|
|regulation of blood vessel endothelial cell migration|
|positive regulation of endothelial cell migration|
|cell-cell junction assembly|
|regulation of NIK/NF-kappaB signaling|
|regulation of osteoblast differentiation|
|cell-cell junction organization|
|positive regulation of epithelial cell migration|
|regulation of endothelial cell migration|
|positive regulation of angiogenesis|
|cell junction assembly|
|positive regulation of vasculature development|
|regulation of ossification|
|cell junction organization|
|regulation of epithelial cell migration|
|transcription corepressor activity|
|negative regulation of cytokine production|
|regulation of angiogenesis|
|regulation of vasculature development|
|histone modification|
|covalent chromatin modification|
|chromatin binding|
|blood vessel morphogenesis|
|protein kinase binding|
|blood vessel development|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|tube morphogenesis|
|regulation of cytokine production|
|chromatin organization|
|negative regulation of cell differentiation|
|tube development|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|regulation of cell motility|
|negative regulation of developmental process|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of response to stimulus|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.77|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.92|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.93|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.15|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.31|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.39|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|3.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13091
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HDAC7 Expression in NALM6 Cells: 5.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>