======= HEATR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HEATR3
  * **<color #00a2e8>Official Name</color>**: HEAT repeat containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55027|55027]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z4Q2|Q7Z4Q2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HEATR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HEATR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614951|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosomal large subunit biogenesis|
|cell|
|protein import into nucleus|
|import into nucleus|
|unfolded protein binding|
|protein import|
|protein localization to nucleus|
|nucleocytoplasmic transport|
|nuclear transport|
|ribosome biogenesis|
|establishment of protein localization to organelle|
|ribonucleoprotein complex biogenesis|
|protein localization to organelle|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-2.29|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.7|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.71|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.73|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.74|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.76|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.79|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.79|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.82|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.87|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.87|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.95|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.98|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.98|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.02|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.04|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.04|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.09|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.19|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.22|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.23|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.3|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|2.5|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.51|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.56|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.57|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.63|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.72|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.75|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.89|
|[[:results:exp134|MS023 2μM R03 exp134]]|3.08|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|3.36|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.65|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|3.91|
|[[:results:exp116|AICAR 240μM R03 exp116]]|4.05|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|4.61|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|5.16|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|6.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpl11|RPL11]]|0.666|
|[[:human genes:r:rpl5|RPL5]]|0.596|
|[[:human genes:g:gtf3a|GTF3A]]|0.515|
|[[:human genes:z:zzz3|ZZZ3]]|0.473|
|[[:human genes:t:tada2a|TADA2A]]|0.468|
|[[:human genes:y:yeats2|YEATS2]]|0.454|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2588
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HEATR3 Expression in NALM6 Cells: 5.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>