======= HECTD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HECTD1
  * **<color #00a2e8>Official Name</color>**: HECT domain E3 ubiquitin protein ligase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25831|25831]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULT8|Q9ULT8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HECTD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HECTD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618649|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure. {ECO:0000250|UniProtKB:Q69ZR2}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|Ank|
|HECT|
|Sad1 UNC|
|MIB HERC2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein K63-linked ubiquitination|
|aorta development|
|heart valve development|
|ventricular septum development|
|artery development|
|cardiac septum development|
|cardiac ventricle development|
|cardiac chamber development|
|ubiquitin-protein transferase activity|
|protein polyubiquitination|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|heart development|
|protein ubiquitination|
|protein modification by small protein conjugation|
|circulatory system development|
|protein modification by small protein conjugation or removal|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.5|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.71|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.76|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.76|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.94|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.04|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zranb1|ZRANB1]]|0.461|
|[[:human genes:a:atxn7l3|ATXN7L3]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 77/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|2/28|
|bone|1/26|
|breast|10/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|3/20|
|lung|8/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|3/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3077
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HECTD1 Expression in NALM6 Cells: 8.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>