======= HELZ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HELZ
  * **<color #00a2e8>Official Name</color>**: helicase with zinc finger
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9931|9931]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42694|P42694]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HELZ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HELZ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606699|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-CCCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|P granule|
|helicase activity|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|gene silencing by RNA|
|gene silencing|
|regulation of gene expression, epigenetic|
|posttranscriptional regulation of gene expression|
|RNA binding|
|ATP binding|
|negative regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.63|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.98|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.97|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.85|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.71|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.77|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:id3|ID3]]|0.435|
|[[:human genes:r:runx1|RUNX1]]|0.427|
|[[:human genes:b:brd9|BRD9]]|0.411|
|[[:human genes:t:tle4|TLE4]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4040
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HELZ Expression in NALM6 Cells: 6.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>