======= HEY1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HEY1
  * **<color #00a2e8>Official Name</color>**: hes related family bHLH transcription factor with YRPW motif 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23462|23462]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5J3|Q9Y5J3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HEY1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HEY1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602953|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). {ECO:0000250|UniProtKB:Q9WV93, ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:15485867, ECO:0000269|PubMed:25985737}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hairy orange|
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|umbilical cord development|
|umbilical cord morphogenesis|
|negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|
|arterial endothelial cell differentiation|
|blood vessel endothelial cell differentiation|
|atrioventricular valve formation|
|dorsal aorta morphogenesis|
|dorsal aorta development|
|Notch signaling involved in heart development|
|heart valve formation|
|heart trabecula formation|
|regulation of vasculogenesis|
|pulmonary valve morphogenesis|
|labyrinthine layer blood vessel development|
|negative regulation of transcription regulatory region DNA binding|
|pulmonary valve development|
|trabecula formation|
|atrioventricular valve morphogenesis|
|cell surface receptor signaling pathway involved in heart development|
|atrioventricular valve development|
|negative regulation of biomineralization|
|cardiac epithelial to mesenchymal transition|
|negative regulation of biomineral tissue development|
|aorta morphogenesis|
|placenta blood vessel development|
|smooth muscle cell differentiation|
|heart trabecula morphogenesis|
|endocardial cushion morphogenesis|
|semi-lunar valve development|
|ventricular septum morphogenesis|
|negative regulation of Notch signaling pathway|
|endocardial cushion development|
|trabecula morphogenesis|
|labyrinthine layer development|
|mesenchyme morphogenesis|
|aorta development|
|heart valve morphogenesis|
|regulation of transcription regulatory region DNA binding|
|negative regulation of DNA binding|
|artery morphogenesis|
|heart valve development|
|epithelial to mesenchymal transition|
|ventricular septum development|
|cardiac ventricle morphogenesis|
|cardiac septum morphogenesis|
|endothelial cell differentiation|
|artery development|
|embryonic placenta development|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|endothelium development|
|regulation of Notch signaling pathway|
|cardiac septum development|
|regulation of DNA binding|
|Notch signaling pathway|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|placenta development|
|mesenchymal cell differentiation|
|protein dimerization activity|
|cardiac chamber development|
|negative regulation of binding|
|anterior/posterior pattern specification|
|mesenchyme development|
|negative regulation of neuron differentiation|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|muscle cell differentiation|
|heart morphogenesis|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|angiogenesis|
|regulation of vasculature development|
|transcription factor binding|
|regionalization|
|negative regulation of cell development|
|regulation of binding|
|in utero embryonic development|
|blood vessel morphogenesis|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|pattern specification process|
|muscle structure development|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|heart development|
|tissue morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.689|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17754
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HEY1 Expression in NALM6 Cells: -1.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>