======= HHIP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HHIP
  * **<color #00a2e8>Official Name</color>**: hedgehog interacting protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64399|64399]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96QV1|Q96QV1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HHIP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HHIP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606178|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. {ECO:0000269|PubMed:11472839, ECO:0000269|PubMed:19561609}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Folate rec|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hedgehog family protein binding|
|epithelial tube branching involved in lung morphogenesis|
|regulation of fibroblast growth factor receptor signaling pathway|
|negative regulation of smoothened signaling pathway|
|neuroblast proliferation|
|lung morphogenesis|
|catalytic activity|
|stem cell proliferation|
|ciliary membrane|
|neural precursor cell proliferation|
|regulation of smoothened signaling pathway|
|dorsal/ventral pattern formation|
|branching morphogenesis of an epithelial tube|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|lung development|
|respiratory tube development|
|respiratory system development|
|skeletal system morphogenesis|
|regulation of cellular response to growth factor stimulus|
|epithelial tube morphogenesis|
|regionalization|
|morphogenesis of an epithelium|
|pattern specification process|
|skeletal system development|
|cell population proliferation|
|tissue morphogenesis|
|cell surface|
|tube morphogenesis|
|zinc ion binding|
|tube development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|animal organ morphogenesis|
|negative regulation of cell death|
|epithelium development|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|neurogenesis|
|regulation of cell death|
|tissue development|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15858
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HHIP Expression in NALM6 Cells: 2.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>