======= HIP1R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HIP1R
  * **<color #00a2e8>Official Name</color>**: huntingtin interacting protein 1 related
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9026|9026]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75146|O75146]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIP1R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIP1R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605613|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. {ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:14732715}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ENTH|
|I LWEQ|
|ANTH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of clathrin coat assembly|
|regulation of clathrin coat assembly|
|positive regulation of platelet-derived growth factor receptor-beta signaling pathway|
|positive regulation of platelet-derived growth factor receptor signaling pathway|
|negative regulation of Arp2/3 complex-mediated actin nucleation|
|regulation of platelet-derived growth factor receptor-beta signaling pathway|
|clathrin light chain binding|
|negative regulation of actin nucleation|
|clathrin adaptor activity|
|regulation of gastric acid secretion|
|AP-2 adaptor complex|
|regulation of Arp2/3 complex-mediated actin nucleation|
|actin cortical patch|
|regulation of clathrin-dependent endocytosis|
|clathrin coat assembly|
|regulation of platelet-derived growth factor receptor signaling pathway|
|synaptic membrane|
|regulation of actin nucleation|
|phosphatidylinositol-3,5-bisphosphate binding|
|phosphatidylinositol-3,4-bisphosphate binding|
|positive regulation of epidermal growth factor receptor signaling pathway|
|dendrite cytoplasm|
|positive regulation of ERBB signaling pathway|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|clathrin binding|
|phosphatidylinositol-3,4,5-trisphosphate binding|
|regulation of digestive system process|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|positive regulation of receptor-mediated endocytosis|
|negative regulation of actin filament polymerization|
|clathrin-coated vesicle|
|negative regulation of protein polymerization|
|regulation of mitochondrial membrane permeability|
|phosphatidylinositol-4,5-bisphosphate binding|
|regulation of membrane permeability|
|regulation of epidermal growth factor receptor signaling pathway|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|phosphatidylinositol binding|
|regulation of ERBB signaling pathway|
|positive regulation of protein binding|
|ruffle membrane|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|positive regulation of mitochondrion organization|
|mitochondrial membrane organization|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|SH3 domain binding|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cytoskeleton organization|
|digestive system development|
|dendritic spine|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of actin filament polymerization|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|positive regulation of binding|
|protein stabilization|
|regulation of mitochondrion organization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of peptidase activity|
|actin filament binding|
|regulation of endocytosis|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|mitochondrial transport|
|regulation of protein binding|
|regulation of protein polymerization|
|receptor-mediated endocytosis|
|actin filament organization|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of protein complex assembly|
|postsynaptic density|
|regulation of actin filament organization|
|regulation of protein stability|
|apical plasma membrane|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|positive regulation of proteolysis|
|neuronal cell body|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of binding|
|regulation of actin filament-based process|
|regulation of apoptotic signaling pathway|
|regulation of endopeptidase activity|
|mitochondrion organization|
|regulation of peptidase activity|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|protein heterodimerization activity|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|regulation of vesicle-mediated transport|
|endocytosis|
|actin filament-based process|
|regulation of system process|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|import into cell|
|intracellular membrane-bounded organelle|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|regulation of secretion|
|cellular protein-containing complex assembly|
|membrane organization|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|negative regulation of cell death|
|programmed cell death|
|identical protein binding|
|cell death|
|cytoskeleton organization|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4047
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIP1R Expression in NALM6 Cells: 5.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>