======= HIRA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HIRA
  * **<color #00a2e8>Official Name</color>**: histone cell cycle regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7290|7290]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54198|P54198]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIRA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIRA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600237|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|HIRA B|
|Hira|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|HIR complex|
|chromatin silencing at centromere|
|nucleosome binding|
|regulation of chromatin silencing|
|DNA replication-independent nucleosome assembly|
|DNA replication-independent nucleosome organization|
|chromosome, centromeric region|
|chromatin silencing|
|chromatin organization involved in negative regulation of transcription|
|chromatin organization involved in regulation of transcription|
|negative regulation of gene expression, epigenetic|
|PML body|
|mitotic sister chromatid segregation|
|nucleosome assembly|
|osteoblast differentiation|
|regulation of gene silencing|
|chromatin assembly|
|sister chromatid segregation|
|mitotic nuclear division|
|gene silencing|
|chromatin assembly or disassembly|
|nucleosome organization|
|gastrulation|
|DNA packaging|
|regulation of chromatin organization|
|protein-DNA complex assembly|
|nuclear chromosome segregation|
|regulation of gene expression, epigenetic|
|nuclear chromatin|
|transcription corepressor activity|
|protein-DNA complex subunit organization|
|muscle cell differentiation|
|ossification|
|chromosome segregation|
|nuclear division|
|DNA conformation change|
|organelle fission|
|regulation of chromosome organization|
|muscle structure development|
|embryonic morphogenesis|
|protein-containing complex|
|mitotic cell cycle process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|mitotic cell cycle|
|chromatin organization|
|cellular protein-containing complex assembly|
|embryo development|
|cell cycle process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.03|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.524|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 336/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|12/28|
|blood|7/28|
|bone|8/25|
|breast|20/33|
|central nervous system|30/56|
|cervix|1/4|
|colorectal|7/17|
|esophagus|2/13|
|fibroblast|1/1|
|gastric|8/15|
|kidney|7/21|
|liver|10/20|
|lung|36/75|
|lymphocyte|4/14|
|ovary|12/26|
|pancreas|10/24|
|peripheral nervous system|9/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|15/24|
|soft tissue|2/7|
|thyroid|1/2|
|upper aerodigestive|8/22|
|urinary tract|12/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 945
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIRA Expression in NALM6 Cells: 6.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>