======= HIST1H1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: H1-5
  * **<color #00a2e8>Official Name</color>**: H1.5 linker histone, cluster member
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3009|3009]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16401|P16401]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIST1H1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIST1H1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142711|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Linker histone|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment of protein localization to chromatin|
|positive regulation of histone H3-K9 methylation|
|establishment of protein localization to chromosome|
|nucleosome positioning|
|negative regulation of chromatin silencing|
|nuclear heterochromatin|
|regulation of histone H3-K9 methylation|
|protein localization to chromatin|
|nuclear euchromatin|
|negative regulation of gene silencing|
|regulation of chromatin silencing|
|positive regulation of histone methylation|
|chromosome condensation|
|nucleosomal DNA binding|
|negative regulation of DNA recombination|
|negative regulation of chromatin organization|
|protein localization to chromosome|
|positive regulation of gene expression, epigenetic|
|regulation of histone methylation|
|nucleosome|
|chromatin DNA binding|
|positive regulation of histone modification|
|double-stranded DNA binding|
|regulation of DNA recombination|
|positive regulation of chromatin organization|
|histone deacetylase binding|
|nucleosome assembly|
|negative regulation of DNA metabolic process|
|regulation of gene silencing|
|negative regulation of chromosome organization|
|chromatin assembly|
|regulation of histone modification|
|chromatin assembly or disassembly|
|nucleosome organization|
|positive regulation of cell growth|
|positive regulation of chromosome organization|
|protein stabilization|
|DNA packaging|
|regulation of chromatin organization|
|protein-DNA complex assembly|
|regulation of gene expression, epigenetic|
|nuclear chromatin|
|protein-DNA complex subunit organization|
|positive regulation of growth|
|regulation of protein stability|
|muscle organ development|
|DNA conformation change|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|negative regulation of organelle organization|
|regulation of cell growth|
|establishment of protein localization to organelle|
|muscle structure development|
|positive regulation of organelle organization|
|regulation of growth|
|chromatin organization|
|negative regulation of cellular component organization|
|protein localization to organelle|
|cellular protein-containing complex assembly|
|negative regulation of transcription by RNA polymerase II|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-2.41|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.32|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.1|
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.04|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.03|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.02|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.01|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.95|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.76|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.77|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|2.02|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.13|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.15|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.37|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.43|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.6|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cramp1l|CRAMP1L]]|0.502|
|[[:human genes:h:hist1h1e|HIST1H1E]]|0.46|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5097
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIST1H1B Expression in NALM6 Cells: 0.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>