======= HIST1H2BA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: H2BC1
  * **<color #00a2e8>Official Name</color>**: H2B clustered histone 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=255626|255626]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96A08|Q96A08]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIST1H2BA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIST1H2BA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609904|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear (PubMed:21249133). {ECO:0000250|UniProtKB:P70696, ECO:0000269|PubMed:21249133}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CBFD NFYB HMF|
|Histone|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spermatogenesis, exchange of chromosomal proteins|
|plasminogen activation|
|sperm chromatin condensation|
|nuclear nucleosome|
|nucleosome disassembly|
|chromatin disassembly|
|protein-DNA complex disassembly|
|spermatid nucleus differentiation|
|extrinsic component of plasma membrane|
|zymogen activation|
|histone exchange|
|mononuclear cell migration|
|nucleosome|
|ATP-dependent chromatin remodeling|
|nuclear chromosome, telomeric region|
|nucleosome assembly|
|histone binding|
|nucleus organization|
|chromatin assembly|
|spermatid development|
|chromatin assembly or disassembly|
|spermatid differentiation|
|nucleosome organization|
|protein processing|
|chromatin remodeling|
|positive regulation of binding|
|DNA packaging|
|protein-DNA complex assembly|
|protein maturation|
|protein-containing complex disassembly|
|protein-DNA complex subunit organization|
|germ cell development|
|DNA conformation change|
|cellular process involved in reproduction in multicellular organism|
|regulation of binding|
|leukocyte migration|
|cellular component disassembly|
|protein heterodimerization activity|
|inflammatory response|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|protein ubiquitination|
|gamete generation|
|chromatin organization|
|molecular function|
|protein modification by small protein conjugation|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|cell migration|
|protein modification by small protein conjugation or removal|
|multi-organism reproductive process|
|chromosome organization|
|cell motility|
|localization of cell|
|proteolysis|
|locomotion|
|defense response|
|reproductive process|
|reproduction|
|DNA binding|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|cell development|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15396
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIST1H2BA Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>