======= HIST2H3D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: H3C13
  * **<color #00a2e8>Official Name</color>**: H3 clustered histone 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=653604|653604]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q71DI3|Q71DI3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIST2H3D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIST2H3D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Histone|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kctd17|KCTD17]]|0.489|
|[[:human genes:d:ddtl|DDTL]]|0.462|
|[[:human genes:p:pan3|PAN3]]|0.45|
|[[:human genes:p:pan2|PAN2]]|0.443|
|[[:human genes:r:rps2|RPS2]]|0.442|
|[[:human genes:c:cbwd3|CBWD3]]|0.437|
|[[:human genes:h:hinfp|HINFP]]|0.431|
|[[:human genes:o:orc1|ORC1]]|0.427|
|[[:human genes:g:golga8o|GOLGA8O]]|0.423|
|[[:human genes:c:chd4|CHD4]]|0.418|
|[[:human genes:c:cbwd5|CBWD5]]|0.417|
|[[:human genes:r:rps19|RPS19]]|0.417|
|[[:human genes:v:vasn|VASN]]|0.41|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.405|
|[[:human genes:w:wdr87|WDR87]]|0.402|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.401|
|[[:human genes:h:hist1h4b|HIST1H4B]]|0.401|
|[[:human genes:c:c14orf93|C14orf93]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 193/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|10/28|
|blood|4/28|
|bone|8/26|
|breast|5/33|
|central nervous system|14/56|
|cervix|4/4|
|colorectal|3/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|7/16|
|kidney|6/21|
|liver|3/20|
|lung|16/75|
|lymphocyte|1/16|
|ovary|4/26|
|pancreas|6/24|
|peripheral nervous system|6/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|10/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1456
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIST2H3D Expression in NALM6 Cells: -3.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>