======= HK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HK1
  * **<color #00a2e8>Official Name</color>**: hexokinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3098|3098]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19367|P19367]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142600|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific. [provided by RefSeq, Apr 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hexokinase 2|
|Hexokinase 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hexokinase activity|
|glucokinase activity|
|maintenance of protein location in mitochondrion|
|fructokinase activity|
|mannokinase activity|
|positive regulation of cytokine secretion involved in immune response|
|glucose binding|
|regulation of cytokine secretion involved in immune response|
|peptidoglycan binding|
|glucose 6-phosphate metabolic process|
|carbohydrate phosphorylation|
|NADH regeneration|
|glucose catabolic process to pyruvate|
|canonical glycolysis|
|glycolytic process through glucose-6-phosphate|
|glycolytic process through fructose-6-phosphate|
|glucose catabolic process|
|positive regulation of interleukin-1 beta secretion|
|NADH metabolic process|
|positive regulation of interleukin-1 secretion|
|maintenance of protein localization in organelle|
|glycolytic process|
|ATP generation from ADP|
|NAD metabolic process|
|regulation of interleukin-1 beta secretion|
|ADP metabolic process|
|positive regulation of interleukin-1 beta production|
|hexose catabolic process|
|regulation of interleukin-1 secretion|
|positive regulation of cytokine production involved in immune response|
|positive regulation of interleukin-1 production|
|nucleoside diphosphate phosphorylation|
|purine ribonucleoside diphosphate metabolic process|
|nucleotide phosphorylation|
|purine nucleoside diphosphate metabolic process|
|monosaccharide catabolic process|
|ribonucleoside diphosphate metabolic process|
|establishment of protein localization to mitochondrion|
|pyruvate metabolic process|
|maintenance of protein location in cell|
|protein localization to mitochondrion|
|regulation of interleukin-1 beta production|
|nucleoside diphosphate metabolic process|
|regulation of cytokine production involved in immune response|
|cellular glucose homeostasis|
|regulation of interleukin-1 production|
|maintenance of location in cell|
|positive regulation of production of molecular mediator of immune response|
|maintenance of protein location|
|glucose metabolic process|
|carbohydrate catabolic process|
|positive regulation of cytokine secretion|
|regulation of production of molecular mediator of immune response|
|hexose metabolic process|
|mitochondrial outer membrane|
|maintenance of location|
|cellular carbohydrate metabolic process|
|glucose homeostasis|
|carbohydrate homeostasis|
|monosaccharide metabolic process|
|ATP metabolic process|
|regulation of cytokine secretion|
|positive regulation of immune effector process|
|membrane raft|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|positive regulation of secretion by cell|
|generation of precursor metabolites and energy|
|positive regulation of protein transport|
|establishment of protein localization to organelle|
|positive regulation of secretion|
|small molecule catabolic process|
|nucleotide metabolic process|
|positive regulation of cytokine production|
|nucleoside phosphate metabolic process|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|carbohydrate metabolic process|
|regulation of peptide secretion|
|monocarboxylic acid metabolic process|
|nucleobase-containing small molecule metabolic process|
|regulation of cytokine production|
|regulation of protein transport|
|protein localization to organelle|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|positive regulation of immune response|
|organophosphate metabolic process|
|cellular homeostasis|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|positive regulation of transport|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|regulation of protein localization|
|identical protein binding|
|chemical homeostasis|
|regulation of immune response|
|positive regulation of immune system process|
|mitochondrion|
|phosphorylation|
|ATP binding|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-3.36|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.49|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.48|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-2.11|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.96|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.86|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.74|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.74|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.74|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.78|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.8|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.82|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.9|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.94|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.96|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.98|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|2.03|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.06|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.07|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.33|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pfkp|PFKP]]|0.6|
|[[:human genes:m:mlf2|MLF2]]|0.527|
|[[:human genes:g:got1|GOT1]]|0.501|
|[[:human genes:h:hk2|HK2]]|0.484|
|[[:human genes:s:slc2a1|SLC2A1]]|0.479|
|[[:human genes:l:lrr1|LRR1]]|0.449|
|[[:human genes:b:bsg|BSG]]|0.441|
|[[:human genes:p:psmd3|PSMD3]]|0.432|
|[[:human genes:o:orc1|ORC1]]|0.427|
|[[:human genes:d:disp2|DISP2]]|0.414|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.414|
|[[:human genes:r:rrm1|RRM1]]|0.412|
|[[:human genes:a:atp1a3|ATP1A3]]|0.408|
|[[:human genes:t:tceb3c|TCEB3C]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1799
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HK1 Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>