======= HK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HK2
  * **<color #00a2e8>Official Name</color>**: hexokinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3099|3099]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52789|P52789]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601125|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hexokinase 2|
|Hexokinase 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hexokinase activity|
|mannokinase activity|
|glucokinase activity|
|maintenance of protein location in mitochondrion|
|fructokinase activity|
|negative regulation of mitochondrial membrane permeability|
|negative regulation of membrane permeability|
|glucose binding|
|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization|
|regulation of autophagy of mitochondrion in response to mitochondrial depolarization|
|positive regulation of autophagy of mitochondrion|
|response to mitochondrial depolarisation|
|glucose 6-phosphate metabolic process|
|carbohydrate phosphorylation|
|glucose catabolic process to pyruvate|
|canonical glycolysis|
|NADH regeneration|
|glycolytic process through fructose-6-phosphate|
|glycolytic process through glucose-6-phosphate|
|glucose catabolic process|
|NADH metabolic process|
|maintenance of protein localization in organelle|
|glycolytic process|
|regulation of autophagy of mitochondrion|
|ATP generation from ADP|
|sarcoplasmic reticulum|
|lactation|
|NAD metabolic process|
|response to ischemia|
|ADP metabolic process|
|hexose catabolic process|
|negative regulation of reactive oxygen species metabolic process|
|regulation of glucose import|
|apoptotic mitochondrial changes|
|nucleoside diphosphate phosphorylation|
|purine nucleoside diphosphate metabolic process|
|monosaccharide catabolic process|
|nucleotide phosphorylation|
|purine ribonucleoside diphosphate metabolic process|
|ribonucleoside diphosphate metabolic process|
|establishment of protein localization to mitochondrion|
|pyruvate metabolic process|
|regulation of mitochondrial membrane permeability|
|regulation of glucose transmembrane transport|
|body fluid secretion|
|maintenance of protein location in cell|
|protein localization to mitochondrion|
|regulation of membrane permeability|
|nucleoside diphosphate metabolic process|
|cellular glucose homeostasis|
|maintenance of location in cell|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|maintenance of protein location|
|glucose metabolic process|
|positive regulation of mitochondrion organization|
|carbohydrate catabolic process|
|positive regulation of autophagy|
|mitochondrial membrane organization|
|mammary gland development|
|hexose metabolic process|
|mitochondrial outer membrane|
|maintenance of location|
|positive regulation of angiogenesis|
|cellular carbohydrate metabolic process|
|regulation of reactive oxygen species metabolic process|
|regulation of mitochondrion organization|
|positive regulation of vasculature development|
|glucose homeostasis|
|carbohydrate homeostasis|
|monosaccharide metabolic process|
|ATP metabolic process|
|mitochondrial transport|
|regulation of angiogenesis|
|purine ribonucleotide metabolic process|
|regulation of vasculature development|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|regulation of autophagy|
|ribose phosphate metabolic process|
|response to hypoxia|
|response to decreased oxygen levels|
|positive regulation of cellular catabolic process|
|purine-containing compound metabolic process|
|response to oxygen levels|
|gland development|
|generation of precursor metabolites and energy|
|positive regulation of catabolic process|
|establishment of protein localization to organelle|
|small molecule catabolic process|
|mitochondrion organization|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|carbohydrate metabolic process|
|regulation of body fluid levels|
|monocarboxylic acid metabolic process|
|nucleobase-containing small molecule metabolic process|
|regulation of transmembrane transport|
|positive regulation of organelle organization|
|protein localization to organelle|
|cellular chemical homeostasis|
|regulation of cellular catabolic process|
|membrane organization|
|organophosphate metabolic process|
|cellular homeostasis|
|carboxylic acid metabolic process|
|apoptotic process|
|oxidation-reduction process|
|regulation of catabolic process|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell death|
|response to cytokine|
|chemical homeostasis|
|secretion|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|phosphorylation|
|regulation of organelle organization|
|positive regulation of developmental process|
|ATP binding|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.18|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.71|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.71|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.72|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.73|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.75|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.76|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.78|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.79|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.81|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.83|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.86|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.86|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.91|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.91|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.94|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.97|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.97|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.99|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|2|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.01|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.02|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.03|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.06|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.08|
|[[:results:exp302|35°C R06 exp302]]|2.23|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.23|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.26|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|2.33|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.51|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.54|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|2.64|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.66|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.67|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.71|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.75|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3.01|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|3.41|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|4.31|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|6.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pfkp|PFKP]]|0.709|
|[[:human genes:g:gpi|GPI]]|0.624|
|[[:human genes:s:slc2a1|SLC2A1]]|0.564|
|[[:human genes:p:pgls|PGLS]]|0.562|
|[[:human genes:p:pgp|PGP]]|0.553|
|[[:human genes:h:hk1|HK1]]|0.484|
|[[:human genes:v:vdac1|VDAC1]]|0.426|
|[[:human genes:a:ahcyl1|AHCYL1]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 315
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HK2 Expression in NALM6 Cells: 7.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>