======= HK3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HK3
  * **<color #00a2e8>Official Name</color>**: hexokinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3101|3101]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52790|P52790]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HK3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HK3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142570|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hexokinase 2|
|Hexokinase 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hexokinase activity|
|mannokinase activity|
|glucokinase activity|
|fructokinase activity|
|glucose binding|
|glucose 6-phosphate metabolic process|
|carbohydrate phosphorylation|
|canonical glycolysis|
|NADH regeneration|
|glucose catabolic process to pyruvate|
|glycolytic process through fructose-6-phosphate|
|glycolytic process through glucose-6-phosphate|
|glucose catabolic process|
|NADH metabolic process|
|glycolytic process|
|ATP generation from ADP|
|NAD metabolic process|
|ADP metabolic process|
|hexose catabolic process|
|nucleoside diphosphate phosphorylation|
|purine nucleoside diphosphate metabolic process|
|monosaccharide catabolic process|
|purine ribonucleoside diphosphate metabolic process|
|nucleotide phosphorylation|
|ribonucleoside diphosphate metabolic process|
|pyruvate metabolic process|
|nucleoside diphosphate metabolic process|
|cellular glucose homeostasis|
|glucose metabolic process|
|secretory granule lumen|
|carbohydrate catabolic process|
|ficolin-1-rich granule lumen|
|hexose metabolic process|
|cellular carbohydrate metabolic process|
|glucose homeostasis|
|carbohydrate homeostasis|
|monosaccharide metabolic process|
|ATP metabolic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|carbohydrate metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|monocarboxylic acid metabolic process|
|nucleobase-containing small molecule metabolic process|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|cellular chemical homeostasis|
|leukocyte mediated immunity|
|exocytosis|
|organophosphate metabolic process|
|cellular homeostasis|
|carboxylic acid metabolic process|
|leukocyte activation|
|oxidation-reduction process|
|oxoacid metabolic process|
|secretion by cell|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|export from cell|
|cell activation|
|immune effector process|
|chemical homeostasis|
|secretion|
|phosphorylation|
|ATP binding|
|homeostatic process|
|small molecule metabolic process|
|organic substance catabolic process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.8|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.83|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.468|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8956
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HK3 Expression in NALM6 Cells: -0.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>