======= HLA-DOB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HLA-DOB
  * **<color #00a2e8>Official Name</color>**: major histocompatibility complex, class II, DO beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3112|3112]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13765|P13765]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HLA-DOB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HLA-DOB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600629|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1-set|
|MHC II beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of antigen processing and presentation of peptide antigen via MHC class II|
|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|negative regulation of antigen processing and presentation of peptide antigen|
|regulation of antigen processing and presentation of peptide antigen via MHC class II|
|regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|regulation of antigen processing and presentation of peptide antigen|
|negative regulation of antigen processing and presentation|
|MHC class II receptor activity|
|MHC class II protein complex binding|
|MHC class II protein complex|
|regulation of antigen processing and presentation|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|endosome membrane|
|antigen processing and presentation|
|lysosome|
|lysosomal membrane|
|negative regulation of immune system process|
|adaptive immune response|
|regulation of immune system process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10683
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.91 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HLA-DOB Expression in NALM6 Cells: 0.91'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>