======= HMGN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HMGN1
  * **<color #00a2e8>Official Name</color>**: high mobility group nucleosome binding domain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3150|3150]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05114|P05114]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HMGN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HMGN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/163920|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HMG14 17|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of NAD+ ADP-ribosyltransferase activity|
|post-embryonic camera-type eye morphogenesis|
|positive regulation of NAD+ ADP-ribosyltransferase activity|
|pyrimidine dimer repair by nucleotide-excision repair|
|post-embryonic eye morphogenesis|
|post-embryonic camera-type eye development|
|post-embryonic animal organ morphogenesis|
|pyrimidine dimer repair|
|post-embryonic animal morphogenesis|
|regulation of development, heterochronic|
|post-embryonic animal organ development|
|response to UV-C|
|response to UV-B|
|positive regulation of DNA-templated transcription, elongation|
|nucleosomal DNA binding|
|regulation of DNA-templated transcription, elongation|
|transcription-coupled nucleotide-excision repair|
|post-embryonic development|
|nucleotide-excision repair|
|camera-type eye morphogenesis|
|chromatin|
|response to UV|
|eye morphogenesis|
|sensory organ morphogenesis|
|response to light stimulus|
|camera-type eye development|
|regulation of epithelial cell proliferation|
|eye development|
|visual system development|
|sensory system development|
|response to radiation|
|DNA repair|
|sensory organ development|
|positive regulation of transferase activity|
|chromatin organization|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|animal organ morphogenesis|
|regulation of transferase activity|
|chromosome organization|
|response to abiotic stimulus|
|positive regulation of catalytic activity|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.433|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13389
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.85 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HMGN1 Expression in NALM6 Cells: 8.85'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>