======= HNRNPA2B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HNRNPA2B1
  * **<color #00a2e8>Official Name</color>**: heterogeneous nuclear ribonucleoprotein A2/B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3181|3181]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22626|P22626]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HNRNPA2B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HNRNPA2B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600124|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non- random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri- miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A- containing pre-mRNAs (PubMed:26321680). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|miRNA transport|
|positive regulation of telomerase RNA reverse transcriptase activity|
|regulation of telomerase RNA reverse transcriptase activity|
|single-stranded telomeric DNA binding|
|G-quadruplex DNA unwinding|
|N6-methyladenosine-containing RNA binding|
|pre-mRNA intronic binding|
|primary miRNA processing|
|G-rich strand telomeric DNA binding|
|negative regulation of mRNA splicing, via spliceosome|
|negative regulation of RNA splicing|
|negative regulation of mRNA processing|
|production of miRNAs involved in gene silencing by miRNA|
|miRNA binding|
|dsRNA processing|
|production of small RNA involved in gene silencing by RNA|
|positive regulation of telomerase activity|
|positive regulation of telomere maintenance via telomere lengthening|
|interleukin-12-mediated signaling pathway|
|gene silencing by miRNA|
|cellular response to interleukin-12|
|response to interleukin-12|
|positive regulation of telomere maintenance|
|chromosome, telomeric region|
|regulation of telomerase activity|
|Cajal body|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|regulation of telomere maintenance via telomere lengthening|
|positive regulation of DNA biosynthetic process|
|mRNA 3-UTR binding|
|negative regulation of mRNA metabolic process|
|regulation of telomere maintenance|
|catalytic step 2 spliceosome|
|gene silencing by RNA|
|spliceosomal complex|
|regulation of mRNA splicing, via spliceosome|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|nuclear matrix|
|regulation of DNA biosynthetic process|
|DNA geometric change|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|regulation of RNA splicing|
|regulation of mRNA processing|
|protein export from nucleus|
|gene silencing|
|ribonucleoprotein complex|
|mRNA transport|
|nuclear export|
|mRNA binding|
|positive regulation of chromosome organization|
|RNA transport|
|nucleic acid transport|
|positive regulation of DNA metabolic process|
|establishment of RNA localization|
|RNA localization|
|regulation of gene expression, epigenetic|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|mRNA splicing, via spliceosome|
|DNA conformation change|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|ncRNA processing|
|RNA splicing|
|ncRNA metabolic process|
|mRNA processing|
|posttranscriptional regulation of gene expression|
|positive regulation of organelle organization|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|mRNA metabolic process|
|negative regulation of transcription by RNA polymerase II|
|RNA processing|
|regulation of transferase activity|
|intracellular protein transport|
|cellular response to cytokine stimulus|
|chromosome organization|
|response to cytokine|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|negative regulation of biosynthetic process|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|negative regulation of gene expression|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-2.16|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.12|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.1|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.09|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.03|
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.02|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.91|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.86|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.76|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|1/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|2/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1845
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HNRNPA2B1 Expression in NALM6 Cells: 10.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>