======= HNRNPAB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HNRNPAB
  * **<color #00a2e8>Official Name</color>**: heterogeneous nuclear ribonucleoprotein A/B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3182|3182]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99729|Q99729]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HNRNPAB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HNRNPAB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602688|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds single-stranded RNA. Has a high affinity for G- rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CBFNT|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sequence-specific double-stranded DNA binding|
|epithelial to mesenchymal transition|
|RNA polymerase II transcription factor complex|
|ribonucleoprotein complex|
|mesenchymal cell differentiation|
|mRNA binding|
|mesenchyme development|
|sequence-specific DNA binding|
|DNA-binding transcription factor activity|
|RNA binding|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-2.11|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.97|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.72|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.9|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.91|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.92|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.97|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.99|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.11|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.14|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|2.18|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.26|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16238
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HNRNPAB Expression in NALM6 Cells: 8.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>