======= HNRNPD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HNRNPD
  * **<color #00a2e8>Official Name</color>**: heterogeneous nuclear ribonucleoprotein D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3184|3184]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14103|Q14103]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HNRNPD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HNRNPD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601324|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CBFNT|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hepatocyte dedifferentiation|
|cellular response to putrescine|
|response to putrescine|
|positive regulation of telomerase RNA reverse transcriptase activity|
|response to rapamycin|
|response to sodium phosphate|
|regulation of telomerase RNA reverse transcriptase activity|
|circadian regulation of translation|
|dedifferentiation|
|cell dedifferentiation|
|AT DNA binding|
|response to ether|
|sequence-specific double-stranded DNA binding|
|cellular response to nitric oxide|
|3-UTR-mediated mRNA destabilization|
|positive regulation of telomere capping|
|response to nitric oxide|
|response to salt|
|cellular response to reactive nitrogen species|
|regulation of telomere capping|
|mRNA 3-UTR AU-rich region binding|
|telomeric DNA binding|
|mRNA destabilization|
|RNA destabilization|
|positive regulation of telomerase activity|
|cellular response to estradiol stimulus|
|mRNA stabilization|
|response to electrical stimulus|
|RNA stabilization|
|positive regulation of mRNA catabolic process|
|positive regulation of telomere maintenance|
|response to bronchodilator|
|regulation of telomerase activity|
|negative regulation of mRNA catabolic process|
|negative regulation of RNA catabolic process|
|positive regulation of DNA biosynthetic process|
|cellular response to amino acid stimulus|
|positive regulation of mRNA metabolic process|
|negative regulation of mRNA metabolic process|
|regulation of telomere maintenance|
|response to antineoplastic agent|
|cerebellum development|
|metencephalon development|
|histone deacetylase binding|
|regulation of DNA biosynthetic process|
|regulation of circadian rhythm|
|response to amino acid|
|positive regulation of translation|
|liver development|
|hepaticobiliary system development|
|negative regulation of translation|
|cellular response to ammonium ion|
|cellular response to reactive oxygen species|
|response to estradiol|
|circadian rhythm|
|negative regulation of cellular amide metabolic process|
|response to calcium ion|
|positive regulation of cellular amide metabolic process|
|hindbrain development|
|ribonucleoprotein complex|
|mRNA binding|
|positive regulation of chromosome organization|
|regulation of mRNA stability|
|response to ammonium ion|
|regulation of RNA stability|
|positive regulation of DNA metabolic process|
|response to ketone|
|response to reactive oxygen species|
|regulation of mRNA catabolic process|
|cellular response to acid chemical|
|cellular response to inorganic substance|
|response to alcohol|
|cellular response to oxidative stress|
|RNA catabolic process|
|negative regulation of cellular catabolic process|
|synapse|
|rhythmic process|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|response to antibiotic|
|negative regulation of catabolic process|
|regulation of mRNA metabolic process|
|transcription factor binding|
|response to acid chemical|
|regulation of chromosome organization|
|regulation of translation|
|regulation of DNA metabolic process|
|positive regulation of cellular catabolic process|
|response to metal ion|
|nucleobase-containing compound catabolic process|
|response to oxidative stress|
|chromatin binding|
|RNA splicing|
|regulation of cellular amide metabolic process|
|cellular response to drug|
|gland development|
|sequence-specific DNA binding|
|positive regulation of catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|mRNA processing|
|organic cyclic compound catabolic process|
|cellular response to lipid|
|posttranscriptional regulation of gene expression|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|mRNA metabolic process|
|brain development|
|head development|
|regulation of cellular catabolic process|
|response to lipid|
|RNA processing|
|cellular macromolecule catabolic process|
|response to hormone|
|response to organic cyclic compound|
|regulation of transferase activity|
|central nervous system development|
|regulation of catabolic process|
|response to organonitrogen compound|
|response to drug|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.83|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.53|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.3|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-2.09|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.98|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.97|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.86|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.84|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.79|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.71|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.71|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.75|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.76|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.77|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|2.07|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.17|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.28|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|2.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:scaf8|SCAF8]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5661
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HNRNPD Expression in NALM6 Cells: 9.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>