======= HOXA11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HOXA11
  * **<color #00a2e8>Official Name</color>**: homeobox A11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3207|3207]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31270|P31270]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HOXA11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HOXA11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142958|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
|DUF3528|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mesodermal cell fate specification|
|embryonic skeletal joint morphogenesis|
|mesodermal cell fate commitment|
|embryonic skeletal joint development|
|organ induction|
|positive regulation of chondrocyte differentiation|
|uterus development|
|mesodermal cell differentiation|
|developmental induction|
|cell fate commitment involved in formation of primary germ layer|
|proximal/distal pattern formation|
|embryonic forelimb morphogenesis|
|positive regulation of cartilage development|
|regulation of animal organ formation|
|forelimb morphogenesis|
|branching involved in ureteric bud morphogenesis|
|protein-DNA complex|
|cartilage development involved in endochondral bone morphogenesis|
|regulation of chondrocyte differentiation|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|embryonic digit morphogenesis|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|mesoderm formation|
|renal tubule morphogenesis|
|mesoderm morphogenesis|
|regulation of cartilage development|
|endochondral bone morphogenesis|
|nephron tubule development|
|renal tubule development|
|dorsal/ventral pattern formation|
|positive regulation of animal organ morphogenesis|
|metanephros development|
|kidney morphogenesis|
|ureteric bud development|
|mesonephric epithelium development|
|mesonephric tubule development|
|cell fate specification|
|mesonephros development|
|embryonic skeletal system morphogenesis|
|nephron epithelium development|
|formation of primary germ layer|
|bone morphogenesis|
|mesoderm development|
|nephron development|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|embryonic skeletal system development|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|male gonad development|
|development of primary male sexual characteristics|
|single fertilization|
|appendage morphogenesis|
|limb morphogenesis|
|male sex differentiation|
|morphogenesis of a branching epithelium|
|gastrulation|
|morphogenesis of a branching structure|
|fertilization|
|cartilage development|
|appendage development|
|limb development|
|bone development|
|transcription factor complex|
|gonad development|
|development of primary sexual characteristics|
|anterior/posterior pattern specification|
|connective tissue development|
|skeletal system morphogenesis|
|cell fate commitment|
|regulation of animal organ morphogenesis|
|sex differentiation|
|kidney development|
|renal system development|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|urogenital system development|
|regionalization|
|developmental growth|
|growth|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|skeletal system development|
|positive regulation of cell development|
|spermatogenesis|
|male gamete generation|
|tissue morphogenesis|
|embryonic morphogenesis|
|protein-containing complex|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell development|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|multi-organism reproductive process|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.04|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.28|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.5|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.7|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|3.21|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|3.27|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|3.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6478
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HOXA11 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>