======= HOXC10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HOXC10
  * **<color #00a2e8>Official Name</color>**: homeobox C10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3226|3226]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NYD6|Q9NYD6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HOXC10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HOXC10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605560|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spinal cord motor neuron cell fate specification|
|proximal/distal pattern formation|
|neuron fate specification|
|spinal cord motor neuron differentiation|
|negative regulation of cold-induced thermogenesis|
|ventral spinal cord development|
|cell differentiation in spinal cord|
|neuron fate commitment|
|cell fate specification|
|spinal cord development|
|neuromuscular process|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|regulation of cold-induced thermogenesis|
|appendage morphogenesis|
|limb morphogenesis|
|central nervous system neuron differentiation|
|limb development|
|appendage development|
|anterior/posterior pattern specification|
|cell fate commitment|
|nuclear body|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regionalization|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|skeletal system development|
|embryonic morphogenesis|
|positive regulation of cell population proliferation|
|embryo development|
|central nervous system development|
|neuron differentiation|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|nervous system process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.07|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.81|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.77|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.75|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.7|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.85|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.85|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|2.07|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|2.07|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9322
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HOXC10 Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>