======= HP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HP
  * **<color #00a2e8>Official Name</color>**: haptoglobin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3240|3240]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00738|P00738]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/140100|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Trypsin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of hydrogen peroxide catabolic process|
|regulation of hydrogen peroxide catabolic process|
|hemoglobin binding|
|negative regulation of cofactor metabolic process|
|negative regulation of hydrogen peroxide metabolic process|
|haptoglobin-hemoglobin complex|
|endocytic vesicle lumen|
|antioxidant activity|
|regulation of hydrogen peroxide metabolic process|
|negative regulation of oxidoreductase activity|
|regulation of cofactor metabolic process|
|acute-phase response|
|negative regulation of reactive oxygen species metabolic process|
|tertiary granule lumen|
|specific granule lumen|
|acute inflammatory response|
|cellular oxidant detoxification|
|regulation of oxidoreductase activity|
|cellular detoxification|
|response to hydrogen peroxide|
|detoxification|
|blood microparticle|
|serine-type endopeptidase activity|
|regulation of reactive oxygen species metabolic process|
|response to reactive oxygen species|
|cellular response to toxic substance|
|receptor-mediated endocytosis|
|negative regulation of cellular catabolic process|
|response to antibiotic|
|negative regulation of catabolic process|
|defense response to bacterium|
|response to oxidative stress|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|inflammatory response|
|neutrophil activation|
|granulocyte activation|
|response to toxic substance|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|response to inorganic substance|
|endocytosis|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|import into cell|
|response to bacterium|
|positive regulation of cell death|
|regulated exocytosis|
|leukocyte mediated immunity|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of cellular catabolic process|
|leukocyte activation|
|defense response to other organism|
|regulation of catabolic process|
|secretion by cell|
|response to drug|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|negative regulation of molecular function|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell death|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18429
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HP Expression in NALM6 Cells: 1.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>